{"product_id":"pex11b-antibody-peroxisomal-membrane-protein-11b-bha17135726","title":"PEX11B Antibody \/ Peroxisomal membrane protein 11B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePEX11B Antibody \/ Peroxisomal membrane protein 11B is a anti-PEX11B Rabbit antibody Recombinant Rabbit Monoclonal clone 29P66 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PEX11B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29P66, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePEX11B antibody detects PEX11B, a peroxisomal biogenesis factor encoded by the PEX11B gene. Other names include peroxisomal membrane protein 11B and PMP11B. PEX11B is a peroxisomal membrane protein that regulates peroxisome proliferation and division. It belongs to the PEX11 family, which control peroxisome number and morphology. PEX11B promotes peroxisomal elongation, constriction, and fission, ensuring proper distribution of peroxisomes during cell division and differentiation. Peroxisomes are essential organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis, making PEX11B critical for cellular homeostasis.\u003cbr\u003e\u003cbr\u003ePEX11B antibody is widely applied in cell biology, metabolism, and disease research. By detecting PEX11B, researchers can explore how peroxisomes multiply and adapt to metabolic demands. Knockout studies show that PEX11B deficiency leads to reduced peroxisome number, altered lipid metabolism, and developmental abnormalities. This highlights its importance in peroxisome biogenesis disorders.\u003cbr\u003e\u003cbr\u003eApplications include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting identifies PEX11B protein in peroxisome enriched fractions, immunohistochemistry maps tissue distribution in liver and kidney, and immunofluorescence highlights peroxisomal membranes. These assays provide robust tools for evaluating peroxisome biology in health and disease.\u003cbr\u003e\u003cbr\u003eMutations in PEX11B cause peroxisome biogenesis disorders characterized by cataracts, intellectual disability, and developmental delay. These disorders illustrate the essential role of PEX11B in organelle maintenance. By applying PEX11B antibody, scientists can investigate peroxisomal dynamics, inheritance, and disease mechanisms. In addition, altered peroxisome function is linked to metabolic syndromes, cancer, and neurodegeneration, making PEX11B relevant beyond rare genetic disease.\u003cbr\u003e\u003cbr\u003ePEX11B interacts with dynamin like proteins and other peroxisome fission factors, coordinating peroxisome proliferation with mitochondrial dynamics. This crosstalk underscores its importance in cellular energy balance.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PEX11B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PEX11B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PEX11B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PEX11B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PEX11B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047303471469,"sku":"FY12824","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6afeaa27-1eaf-4e97-b29e-3c6ec1f41924.jpg?v=1782237043","url":"https:\/\/www.ebiohippo.com\/products\/pex11b-antibody-peroxisomal-membrane-protein-11b-bha17135726","provider":"BioHippo","version":"1.0","type":"link"}