{"product_id":"pex19-antibody-peroxisomal-biogenesis-factor-19-bha17135871","title":"PEX19 Antibody \/ Peroxisomal biogenesis factor 19","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePEX19 Antibody \/ Peroxisomal biogenesis factor 19 is a anti-PEX19 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PEX19\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePEX19 antibody detects Peroxisomal biogenesis factor 19, a cytosolic chaperone and receptor required for peroxisome membrane assembly. The UniProt recommended name is Peroxisomal biogenesis factor 19 (PEX19). This protein is essential for the import and insertion of peroxisomal membrane proteins (PMPs), ensuring proper peroxisome formation, maintenance, and function.\u003cbr\u003e\u003cbr\u003eFunctionally, PEX19 antibody recognizes a 299-amino-acid protein that binds newly synthesized PMPs in the cytosol, shielding them from aggregation and misfolding. PEX19 delivers these PMPs to the peroxisomal membrane by interacting with the docking protein PEX3, which anchors them into the membrane bilayer. This process is vital for peroxisomal membrane protein biogenesis, division, and inheritance. PEX19 functions both as a chaperone and an import receptor, playing a dual role in organelle biogenesis.\u003cbr\u003e\u003cbr\u003eThe PEX19 gene is located on chromosome 1q22 and encodes a soluble protein that cycles between cytosolic and peroxisomal compartments. It contains a C-terminal farnesylation motif that anchors it transiently to membranes, enhancing interaction with peroxisomal receptors. Mutations in PEX19 cause peroxisome biogenesis disorder type 14B (Zellweger spectrum disorder), resulting in defective peroxisome formation and metabolic dysfunction characterized by accumulation of very-long-chain fatty acids and bile acid intermediates.\u003cbr\u003e\u003cbr\u003eIn healthy cells, PEX19 interacts with multiple peroxins, including PEX3 and PEX16, forming a network that ensures correct targeting and integration of PMPs. Its function is tightly coordinated with matrix protein import, supporting peroxisomal maintenance and proliferation. Beyond peroxisome assembly, PEX19 may influence lipid metabolism and antioxidant defense through its role in peroxisomal homeostasis. Dysregulation of PEX19 expression contributes to oxidative stress and metabolic imbalance.\u003cbr\u003e\u003cbr\u003ePEX19 antibody is used in cell biology, biochemistry, and metabolism research to study peroxisomal formation and dynamics. It supports applications such as immunoblotting, immunofluorescence, and organelle isolation to evaluate peroxisome abundance, protein import, and morphology. The antibody is especially valuable for identifying peroxisomal defects in metabolic and neurodegenerative diseases. In hepatocytes and fibroblasts, PEX19 localization provides a sensitive indicator of peroxisome assembly status.\u003cbr\u003e\u003cbr\u003eStructurally, PEX19 contains multiple tetratricopeptide repeat (TPR)-like motifs that mediate binding to PMPs. Its N-terminal region recognizes hydrophobic transmembrane segments, while the C-terminal farnesylation site facilitates membrane targeting.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PEX19 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PEX19 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PEX19 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PEX19 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PEX19+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047308484973,"sku":"FY12969","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fea75172-4e30-49e7-a9e7-c4ab50593375.jpg?v=1782237073","url":"https:\/\/www.ebiohippo.com\/products\/pex19-antibody-peroxisomal-biogenesis-factor-19-bha17135871","provider":"BioHippo","version":"1.0","type":"link"}