{"product_id":"pgm1-antibody-phosphoglucomutase-1-bha17136203","title":"PGM1 Antibody \/ Phosphoglucomutase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePGM1 Antibody \/ Phosphoglucomutase 1 is a anti-PGM1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30P21 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PGM1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30P21, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePGM1 antibody detects Phosphoglucomutase 1, encoded by the PGM1 gene. Phosphoglucomutase 1 is a key metabolic enzyme that catalyzes the reversible conversion of glucose-1-phosphate and glucose-6-phosphate, thereby linking glycogen metabolism with glycolysis and gluconeogenesis. PGM1 antibody provides researchers with an important reagent to study carbohydrate metabolism, energy regulation, and metabolic disorders.\u003cbr\u003e\u003cbr\u003ePhosphoglucomutase 1 functions as a critical branch-point enzyme, controlling the flux of glucose molecules between storage and utilization pathways. Research using PGM1 antibody has shown that its activity is essential for maintaining blood glucose levels during fasting and feeding cycles. The enzyme is expressed in most tissues, but is particularly abundant in liver and muscle, where it helps balance glycogen reserves with immediate energy needs. This makes Phosphoglucomutase 1 indispensable for metabolic flexibility.\u003cbr\u003e\u003cbr\u003eStudies with PGM1 antibody have revealed that deficiency in this enzyme leads to PGM1 deficiency, also known as glycogen storage disease type XIV. Patients present with hypoglycemia, hepatomegaly, exercise intolerance, and sometimes congenital disorders of glycosylation, as the enzyme also contributes to protein glycosylation pathways. Mutations in PGM1 impair enzymatic activity, demonstrating the broad role of this protein in both energy metabolism and protein processing.\u003cbr\u003e\u003cbr\u003eIn cancer research, Phosphoglucomutase 1 has gained attention as a metabolic regulator. Studies with PGM1 antibody have shown that altered expression levels can reprogram glucose metabolism to support rapid tumor growth. By increasing glycolytic flux and maintaining biosynthetic precursors, PGM1 supports cell proliferation. This positions it as a potential biomarker for metabolic adaptation in cancer.\u003cbr\u003e\u003cbr\u003ePGM1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies protein levels and detects isoforms, immunohistochemistry reveals tissue distribution in metabolic organs, and immunofluorescence highlights cytoplasmic localization associated with glycogen granules. These experimental applications make PGM1 antibody valuable in basic and clinical research.\u003cbr\u003e\u003cbr\u003eBy supplying validated PGM1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PGM1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PGM1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PGM1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PGM1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PGM1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047321985389,"sku":"FY13301","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_33898e16-6d04-43cf-a9db-dc93e79f398f.jpg?v=1772019422","url":"https:\/\/www.ebiohippo.com\/products\/pgm1-antibody-phosphoglucomutase-1-bha17136203","provider":"BioHippo","version":"1.0","type":"link"}