{"product_id":"phenylacetyl-coenzyme-a-sodium-salt-bhb21200049","title":"Phenylacetyl Coenzyme A, Sodium salt","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003ePhenylacetyl Coenzyme A, Sodium salt is a biochemical supplied by Coenza for use in enzymology and metabolic research. Available as Lyophilized powder, purity ≥ 95%, suitable for in vitro assays and pathway studies.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso known as:\u003c\/em\u003e Phenylacetyl-CoA sodium, Phenylacetyl-CoA Na salt.\u003c\/p\u003e\n\u003ch2\u003eKey Elements and Design Rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula \/ MW \/ Purity:\u003c\/strong\u003e C29H39N7O17P3S · xNa; 885.67 g\/mol (free acid basis); ≥ 95%. The Sodium salt form provides enhanced aqueous stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm \/ Solubility:\u003c\/strong\u003e Lyophilized powder; Soluble in water.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Phenylacetyl-CoA sodium, Phenylacetyl-CoA Na salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Biosynthetic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003ePhenylacetyl coenzyme A (Phenylacetyl-CoA) is used to investigate the mechanisms of the TetR family transcriptional repressor PaaR, which regulates genes involved in phenylacetic acid (PAA) degradation in bacteria like Escherichia coli. Phenylacetyl-CoA binds to PaaR, leading to derepression and activation of the PAA catabolic operon. Phenylacetyl-CoA serves as a substrate for the phenylacetyl-CoA monooxygenase complex, which plays a key role in the breakdown of phenylacetic acid and related aromatic compounds in these bacteria (Grishin et al., 2011; Sakamoto et al., 2011).\u003c\/p\u003e\n\u003ch2\u003eResearch Relevance and Current Trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcyl-CoA metabolism increasingly linked to histone acylation marks and epigenetic regulation in cancer and metabolic disease research.\u003c\/li\u003e\n\u003cli\u003eGrowing interest in short-chain fatty acid CoA thioesters as mediators of gut microbiome–host metabolic crosstalk.\u003c\/li\u003e\n\u003cli\u003eCoA-dependent enzymes investigated as drug targets in infectious disease and neurometabolic disorder research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon Research Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnzyme kinetics assays — direct substrate for acyltransferases, thiolases, and dehydrogenases.\u003c\/li\u003e\n\u003cli\u003eMetabolic flux analysis — isotope-labeled variants available for stable-isotope tracing.\u003c\/li\u003e\n\u003cli\u003eIn vitro pathway reconstitution for fatty acid β-oxidation, TCA cycle, or polyketide biosynthesis.\u003c\/li\u003e\n\u003cli\u003eBiochemical characterization of CoA-binding proteins by activity assays or binding measurements.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eNotes for Experimental Interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCoA thioesters hydrolyze at neutral–alkaline pH; prepare working solutions fresh and keep on ice.\u003c\/li\u003e\n\u003cli\u003eDifferent salt forms share the same core structure — normalize concentrations using the free-acid MW when comparing across forms.\u003c\/li\u003e\n\u003cli\u003eThiol oxidation may occur upon air exposure; use under inert atmosphere or with reducing agents where appropriate.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Coenza","offers":[{"title":"10 mg","offer_id":53249726251373,"sku":"A-49-10MG","price":1312.5,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53249733886317,"sku":"A-49-25MG","price":2375.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/53dbfa_a944f26afdc247ceb90de90c7f619192_mv2.png?v=1776855584","url":"https:\/\/www.ebiohippo.com\/products\/phenylacetyl-coenzyme-a-sodium-salt-bhb21200049","provider":"BioHippo","version":"1.0","type":"link"}