{"product_id":"phospho-caveolin-1-tyr14-antibody-cav1-bha17136166","title":"Phospho-Caveolin 1 (Tyr14) Antibody \/ CAV1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-Caveolin 1 (Tyr14) Antibody \/ CAV1 is a anti-CAV1 (phospho-Tyr14) Rabbit antibody Recombinant Rabbit Monoclonal clone 32C49 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CAV1 (phospho site: Tyr14)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32C49, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-Caveolin 1 (Tyr14) antibody detects Caveolin 1 phosphorylated at tyrosine 14, encoded by the CAV1 gene. Caveolin 1 is an integral membrane protein and principal component of caveolae, small invaginations in the plasma membrane involved in endocytosis, cholesterol homeostasis, and signal transduction. Phosphorylation at tyrosine 14 is a key regulatory modification that alters Caveolin 1 function and interactions with signaling molecules. Phospho-Caveolin 1 (Tyr14) antibody provides researchers with a powerful tool for investigating membrane dynamics and signaling pathways regulated by caveolae.\u003cbr\u003e\u003cbr\u003eCaveolin 1 acts as a scaffolding protein that organizes signaling complexes at the plasma membrane. Research using Phospho-Caveolin 1 (Tyr14) antibody has demonstrated that phosphorylation at tyrosine 14 is mediated primarily by Src family kinases in response to growth factors, mechanical stress, or cellular adhesion events. This modification induces conformational changes that modulate protein interactions and influence downstream signaling. By altering binding partners, phosphorylation at Tyr14 affects processes such as focal adhesion turnover, cell migration, and proliferation.\u003cbr\u003e\u003cbr\u003eStudies with Phospho-Caveolin 1 (Tyr14) antibody have shown that this modification regulates integrin signaling and cytoskeletal dynamics. Phosphorylated Caveolin 1 promotes disassembly of focal adhesions, allowing cells to migrate during wound healing, angiogenesis, and cancer metastasis. It also participates in mechanotransduction, enabling cells to sense and respond to changes in extracellular matrix stiffness or fluid shear stress. These findings highlight the versatility of Caveolin 1 phosphorylation as a regulatory switch in cell biology.\u003cbr\u003e\u003cbr\u003eDysregulation of Caveolin 1 phosphorylation has been linked to multiple diseases. Research using Phospho-Caveolin 1 (Tyr14) antibody has revealed altered phosphorylation in cancer, where excessive modification promotes tumor cell invasion and metastasis. In cardiovascular disease, abnormal Caveolin 1 phosphorylation disrupts endothelial function and contributes to vascular pathology. In pulmonary fibrosis, changes in Caveolin 1 phosphorylation status affect fibroblast activation and extracellular matrix remodeling. These diverse roles emphasize its broad clinical relevance.\u003cbr\u003e\u003cbr\u003ePhospho-Caveolin 1 (Tyr14) antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated Caveolin 1 from its unmodified form, immunohistochemistry identifies activated signaling domains in tissues, and immunofluorescence visualizes phosphorylated Caveolin 1 within caveolae at the plasma membrane. These applications make the antibody indispensable for cell signaling and membrane biology research.\u003cbr\u003e\u003cbr\u003eBy providing validated Phospho-Caveolin 1 (Tyr14) antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CAV1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CAV1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CAV1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CAV1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CAV1+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=CAV1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047319888237,"sku":"FY13264","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/phospho-caveolin-1-tyr14-antibody-cav1-bha17136166","provider":"BioHippo","version":"1.0","type":"link"}