{"product_id":"phospho-glut4-ser488-antibody-slc2a4-bha17136247","title":"Phospho-GLUT4 (Ser488) Antibody \/ SLC2A4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-GLUT4 (Ser488) Antibody \/ SLC2A4 is a anti-GLUT4 (phospho-Ser488) Rabbit antibody Recombinant Rabbit Monoclonal clone 32S34 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GLUT4 (phospho site: Ser488)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32S34, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-GLUT4 (Ser488) antibody detects GLUT4 phosphorylated at serine 488, encoded by the SLC2A4 gene. GLUT4 is an insulin responsive glucose transporter that regulates cellular glucose uptake, particularly in adipose tissue and skeletal muscle. Phospho-GLUT4 (Ser488) antibody provides researchers with a highly specific reagent to study glucose transport regulation, insulin signaling, and metabolic disease.\u003cbr\u003e\u003cbr\u003eGLUT4 is stored in intracellular vesicles under basal conditions and translocates to the plasma membrane in response to insulin stimulation. Research using Phospho-GLUT4 (Ser488) antibody has shown that phosphorylation at Ser488 modulates GLUT4 trafficking and activity, influencing how cells respond to hormonal signals. This modification connects insulin receptor activation with downstream control of glucose uptake.\u003cbr\u003e\u003cbr\u003eStudies with Phospho-GLUT4 (Ser488) antibody have revealed that phosphorylation at Ser488 is mediated by kinases activated during insulin signaling, including Akt and related pathways. This modification fine tunes the balance between vesicular storage and surface localization, ensuring that glucose uptake matches metabolic demands. Dysregulation of GLUT4 phosphorylation impairs glucose handling and contributes to insulin resistance.\u003cbr\u003e\u003cbr\u003eIn type 2 diabetes and obesity, abnormal GLUT4 trafficking is a hallmark feature. Research using Phospho-GLUT4 (Ser488) antibody has demonstrated that altered phosphorylation disrupts GLUT4 translocation, leading to reduced glucose uptake in muscle and adipose tissue. This impairment contributes directly to hyperglycemia and metabolic imbalance. Targeting GLUT4 phosphorylation is being investigated as a strategy to restore glucose homeostasis in diabetes therapy.\u003cbr\u003e\u003cbr\u003ePhospho-GLUT4 (Ser488) antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total GLUT4 protein, immunohistochemistry localizes activated transporter in tissue sections, and immunofluorescence reveals dynamic trafficking patterns in cells. These applications make the antibody indispensable for metabolic research.\u003cbr\u003e\u003cbr\u003eBy providing validated Phospho-GLUT4 (Ser488) antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GLUT4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GLUT4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GLUT4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GLUT4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GLUT4+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=GLUT4 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047323361645,"sku":"FY13345","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6a1a3337-a943-4561-89c4-12e62de98149.jpg?v=1772019431","url":"https:\/\/www.ebiohippo.com\/products\/phospho-glut4-ser488-antibody-slc2a4-bha17136247","provider":"BioHippo","version":"1.0","type":"link"}