{"product_id":"phospho-lrp6-ser1490-antibody-low-density-lipoprotein-receptor-related-protein-6-bha17135843","title":"Phospho-LRP6 (Ser1490) Antibody \/ Low density lipoprotein receptor related protein 6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-LRP6 (Ser1490) Antibody \/ Low density lipoprotein receptor related protein 6 is a anti-LRP6 (phospho-Ser1490) Rabbit antibody Recombinant Rabbit Monoclonal clone 31L42 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LRP6 (phospho site: Ser1490)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31L42, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-LRP6 (Ser1490) antibody detects the phosphorylated form of Low density lipoprotein receptor related protein 6, encoded by the LRP6 gene. LRP6 is a single pass transmembrane receptor that serves as a critical co receptor in the canonical Wnt signaling pathway. This receptor works together with the Frizzled family of proteins to transmit Wnt signals into the cell, leading to stabilization of beta catenin and activation of Wnt target genes. Phosphorylation at serine 1490 is a key activation step that amplifies the signaling cascade, and Phospho-LRP6 (Ser1490) antibody provides a precise tool to study Wnt pathway activation in both normal physiology and disease contexts.\u003cbr\u003e\u003cbr\u003eLow density lipoprotein receptor related protein 6 is phosphorylated by kinases such as GSK3 and CK1 following Wnt ligand binding. Serine 1490 is one of the critical sites required for recruitment of the cytoplasmic effector Dishevelled and for inhibition of the beta catenin destruction complex. Research using Phospho-LRP6 (Ser1490) antibody has shown that phosphorylation at this site acts as a molecular switch, turning on downstream signaling. Without phosphorylation at serine 1490, Wnt mediated gene expression is severely impaired, demonstrating the importance of this modification in developmental and disease related signaling events.\u003cbr\u003e\u003cbr\u003eAberrant Wnt signaling is implicated in multiple cancers, including colorectal carcinoma, breast cancer, and hepatocellular carcinoma. Overexpression or hyperactivation of LRP6 contributes to increased beta catenin stabilization, driving oncogenic transcriptional programs. Studies employing Phospho-LRP6 (Ser1490) antibody have revealed that elevated phosphorylation correlates with poor prognosis and aggressive tumor progression. Beyond cancer, abnormal regulation of LRP6 phosphorylation is also associated with bone disorders, atherosclerosis, and neurodegenerative disease, highlighting the broad relevance of this receptor.\u003cbr\u003e\u003cbr\u003ePhospho-LRP6 (Ser1490) antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting allows quantification of phosphorylated versus unphosphorylated forms, providing a readout of Wnt activation. Immunohistochemistry demonstrates tissue specific activation of Wnt signaling, while immunofluorescence visualizes membrane localized phosphorylation events in cell culture models. Researchers studying embryonic development, stem cell biology, and tumor progression use Phospho-LRP6 (Ser1490) antibody to dissect pathway activity with high specificity.\u003cbr\u003e\u003cbr\u003eBy providing validated reagents such as Phospho-LRP6 (Ser1490) antibody,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LRP6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LRP6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LRP6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LRP6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LRP6+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=LRP6 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047306715501,"sku":"FY12941","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ec21b43d-98a1-4fb7-bca3-1ad435b9bc10.jpg?v=1772019368","url":"https:\/\/www.ebiohippo.com\/products\/phospho-lrp6-ser1490-antibody-low-density-lipoprotein-receptor-related-protein-6-bha17135843","provider":"BioHippo","version":"1.0","type":"link"}