{"product_id":"phospho-pdgf-receptor-beta-tyr1021-antibody-cd140b-bha17135657","title":"Phospho-PDGF Receptor beta (Tyr1021) Antibody \/ CD140b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-PDGF Receptor beta (Tyr1021) Antibody \/ CD140b is a anti-PDGF (phospho-Tyr1021) Rabbit antibody Recombinant Rabbit Monoclonal clone 32P59 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDGF (phospho site: Tyr1021)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32P59, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-PDGF Receptor beta (Tyr1021) antibody detects platelet derived growth factor receptor beta when phosphorylated at tyrosine 1021. PDGFR beta, encoded by the PDGFRB gene, is also referred to as CD140b and PDGFR2. It is a receptor tyrosine kinase expressed on mesenchymal cells, smooth muscle, and pericytes. Upon ligand binding, PDGFR beta dimerizes and undergoes autophosphorylation at multiple tyrosines, including Tyr1021, which serves as a binding site for PLC gamma and other signaling proteins. This event is critical for downstream pathways regulating proliferation, migration, and angiogenesis.\u003cbr\u003e\u003cbr\u003ePhospho-PDGF Receptor beta (Tyr1021) antibody is widely applied in cancer research, vascular biology, and fibrosis studies. By detecting phosphorylation at Tyr1021, researchers can evaluate receptor activation and downstream signaling status in diverse contexts. This site specific phosphorylation links PDGFR beta to phosphoinositide hydrolysis, calcium mobilization, and mitogenic signaling.\u003cbr\u003e\u003cbr\u003e Western blot assays distinguish phosphorylated PDGFR beta from unphosphorylated receptor, immunohistochemistry maps receptor activation in tumor vasculature and fibrotic tissues, and immunofluorescence highlights receptor localization at the plasma membrane. These assays provide direct evidence of receptor signaling in situ.\u003cbr\u003e\u003cbr\u003eDysregulation of PDGFR beta signaling contributes to cancers, vascular malformations, and fibrotic disease. Activating mutations and gene fusions involving PDGFRB drive leukemias and solid tumors. Excessive phosphorylation promotes pathological vessel growth and fibrosis. Phospho-PDGF Receptor beta (Tyr1021) antibody supports mechanistic studies and translational research into targeted therapies such as tyrosine kinase inhibitors. Measuring Tyr1021 phosphorylation also provides pharmacodynamic biomarkers for drug development.\u003cbr\u003e\u003cbr\u003ePhospho-PDGF Receptor beta (Tyr1021) antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDGF - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDGF - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDGF - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDGF - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDGF+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=PDGF --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047299277165,"sku":"FY12754","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/phospho-pdgf-receptor-beta-tyr1021-antibody-cd140b-bha17135657","provider":"BioHippo","version":"1.0","type":"link"}