{"product_id":"phospho-pdgfr-beta-tyr1009-antibody-bha17135577","title":"Phospho-PDGFR beta (Tyr1009) Antibody","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-PDGFR beta (Tyr1009) Antibody is a anti-PDGFR (phospho-Tyr1009) Rabbit antibody Recombinant Rabbit Monoclonal clone 32P51 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDGFR (phospho site: Tyr1009)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32P51, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-PDGFR beta (Tyr1009) antibody detects platelet derived growth factor receptor beta when phosphorylated at tyrosine 1009. PDGFR beta, encoded by the PDGFRB gene, is a receptor tyrosine kinase that regulates cell growth, survival, migration, and angiogenesis. Binding of platelet derived growth factor ligands induces receptor dimerization and autophosphorylation at multiple sites. Phosphorylation at Tyr1009 creates a docking site for signaling molecules such as phospholipase C gamma, initiating downstream cascades including MAPK and PI3K pathways. This modification is required for full receptor signaling and biological activity.\u003cbr\u003e\u003cbr\u003ePhospho-PDGFR beta (Tyr1009) antibody is widely applied in cancer biology, cardiovascular research, and developmental biology. PDGFR beta is essential for vascular development, pericyte recruitment, and wound healing. Aberrant phosphorylation contributes to oncogenesis, fibrotic disease, and abnormal angiogenesis. By detecting phosphorylation at Tyr1009, researchers can assess PDGFR beta activation status in normal and pathological contexts.\u003cbr\u003e\u003cbr\u003e Western blot assays detect phosphorylated PDGFR beta distinct from unmodified protein. Immunohistochemistry maps receptor activation in tumors and vascular tissues, while immunofluorescence highlights membrane localization at sites of ligand stimulation. These methods allow precise analysis of receptor phosphorylation in situ.\u003cbr\u003e\u003cbr\u003eAberrant PDGFR beta phosphorylation has been linked to glioblastoma, leukemia, and sarcomas. Targeted therapies such as tyrosine kinase inhibitors aim to suppress PDGFR signaling, and phospho specific antibodies provide biomarkers for drug efficacy. By applying Phospho-PDGFR beta (Tyr1009) antibody, scientists can investigate therapeutic mechanisms, evaluate resistance pathways, and develop improved interventions.\u003cbr\u003e\u003cbr\u003ePDGFR beta phosphorylation is also important in cardiovascular disease and tissue repair. It regulates smooth muscle proliferation, vascular remodeling, and fibrotic responses. Dysregulation leads to hypertension, atherosclerosis, and organ fibrosis. The phospho-specific antibody therefore supports research across oncology, cardiology, and regenerative medicine.\u003cbr\u003e\u003cbr\u003ePhospho-PDGFR beta (Tyr1009) antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDGFR - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDGFR - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDGFR - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDGFR - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDGFR+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=PDGFR --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047296164205,"sku":"FY12674","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/phospho-pdgfr-beta-tyr1009-antibody-bha17135577","provider":"BioHippo","version":"1.0","type":"link"}