{"product_id":"phospho-plcb3-ser537-antibody-phospholipase-c-beta-3-bha17135153","title":"Phospho-PLCB3 (Ser537) Antibody \/ Phospholipase C beta 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-PLCB3 (Ser537) Antibody \/ Phospholipase C beta 3 is an antibody targeting \u003cstrong\u003ePhospho-PLCB3\u003c\/strong\u003e. Host: \u003cstrong\u003eRabbit\u003c\/strong\u003e. Monoclonal. Clone: \u003cstrong\u003e32P57\u003c\/strong\u003e. Format: Liquid. Applications: WB.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Phospho-PLCB3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunogen:\u003c\/strong\u003e A synthesized peptide derived from human Phospho-PLCB3 (S537) was used as the immunogen for the Phospho-PLCB3 (Ser537)….\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e Unconjugated (no label listed).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background (from provided description)\u003c\/h2\u003e\u003cp\u003ePhospho-PLCB3 (Ser537) antibody detects phospholipase C beta 3 (PLCB3) phosphorylated at serine 537, a modification that regulates enzyme activity and signaling. PLCB3 is a member of the phospholipase C family of enzymes, which hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) to generate second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG).\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWB:\u003c\/strong\u003e relative abundance and band pattern assessment using appropriate controls.\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eAccount for isoforms, paralogs, and post-translational modifications when interpreting signal.\u003c\/li\u003e\n\u003cli\u003eSupport specificity with biological controls (e.g., KO\/KD where available) and technical controls (e.g., secondary-only\/isotype).\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt) – https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NLM) – https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - ZFIN – https:\/\/zfin.org\/ - Ensembl – https:\/\/www.ensembl.org\/ - Nature Methods (2015): A proposal for validation of antibodies – https:\/\/www.nature.com\/articles\/nmeth.3230 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53046720364909,"sku":"FY12250","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f8e3a4c9-bfca-487d-9259-f2a8434229e5.jpg?v=1772010436","url":"https:\/\/www.ebiohippo.com\/products\/phospho-plcb3-ser537-antibody-phospholipase-c-beta-3-bha17135153","provider":"BioHippo","version":"1.0","type":"link"}