{"product_id":"phospho-protein-kinase-d2-ser876-antibody-prkd2-bha17135988","title":"Phospho-Protein Kinase D2 (Ser876) Antibody \/ PRKD2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-Protein Kinase D2 (Ser876) Antibody \/ PRKD2 is a anti-D2 (phospho-Ser876) Rabbit antibody Recombinant Rabbit Monoclonal clone 32P58 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e D2 (phospho site: Ser876)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32P58, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-Protein kinase D2 (Ser876) antibody detects Protein kinase D2 phosphorylated at serine 876, encoded by the PRKD2 gene. Protein kinase D2 is a member of the protein kinase D family of serine threonine kinases that integrate signals from diacylglycerol, protein kinase C, and G protein coupled receptors. Phosphorylation at serine 876 is a critical regulatory event required for full catalytic activity. Phospho-Protein kinase D2 (Ser876) antibody provides researchers with a precise tool to study PRKD2 signaling in cell proliferation, migration, and inflammation.\u003cbr\u003e\u003cbr\u003eProtein kinase D2 plays a central role in diverse cellular pathways, including vesicle trafficking, oxidative stress responses, and cytoskeletal remodeling. Studies with Phospho-Protein kinase D2 (Ser876) antibody have shown that phosphorylation at serine 876 occurs within the activation loop of the kinase domain, stabilizing active conformations and promoting downstream signaling. Activation of PRKD2 influences nuclear factor kappa B activity, gene expression, and secretion of cytokines. This modification thus represents a key regulatory switch linking extracellular signals to transcriptional responses.\u003cbr\u003e\u003cbr\u003ePRKD2 has been implicated in oncogenesis, cardiovascular disease, and immune regulation. Research using Phospho-Protein kinase D2 (Ser876) antibody has revealed that hyperactivation of PRKD2 promotes tumor growth, angiogenesis, and metastasis by stimulating survival and motility pathways. In the cardiovascular system, phosphorylation of PRKD2 influences contraction, vascular permeability, and stress responses. Its role in immune signaling involves regulation of T cell receptor pathways and cytokine secretion. The breadth of these functions underscores the importance of monitoring phosphorylation status.\u003cbr\u003e\u003cbr\u003eBeyond physiological roles, PRKD2 has become a potential therapeutic target. Small molecule inhibitors that block PRKD activation have been investigated in preclinical cancer and inflammatory models. Phospho-Protein kinase D2 (Ser876) antibody is a valuable tool in assessing drug effects by specifically detecting activation state. Such reagents allow researchers to dissect how therapies modulate phosphorylation dependent PRKD2 signaling and how this impacts cellular outcomes.\u003cbr\u003e\u003cbr\u003ePhospho-Protein kinase D2 (Ser876) antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total PRKD2, while immunohistochemistry reveals activation patterns in tissue samples. Immunofluorescence demonstrates dynamic localization changes upon stimulation, providing insight into subcellular distribution of active kinase. These applications make the antibody essential for signaling research.\u003cbr\u003e\u003cbr\u003eBy supplying validated Phospho-Protein kinase D2 (Ser876) antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=D2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=D2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=D2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/D2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=D2+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=D2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047311860077,"sku":"FY13086","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/phospho-protein-kinase-d2-ser876-antibody-prkd2-bha17135988","provider":"BioHippo","version":"1.0","type":"link"}