{"product_id":"phospho-tau-antibody-ps324-bha17136369","title":"Phospho-Tau Antibody pS324","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-Tau Antibody pS324 is a anti-Tau Rabbit antibody Recombinant Rabbit Monoclonal clone 17M40 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Tau\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 17M40, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho Tau antibody pS324 is a specialized research reagent for investigating tau phosphorylation, neurodegeneration, and cytoskeletal regulation. The encoded protein, tau, is a microtubule associated protein that stabilizes microtubules in neurons and regulates axonal transport. Aberrant phosphorylation of tau at specific serine and threonine residues is a hallmark of tauopathies, including Alzheimer disease and other neurodegenerative disorders. This antibody recognizes tau only when serine at amino acid 324 is phosphorylated, providing a precise tool for detecting disease related phosphorylation states.\u003cbr\u003e\u003cbr\u003ePhosphorylation at serine 324 occurs within the proline rich domain of tau, a region critical for microtubule binding and protein interactions. Modification at this site has been associated with reduced microtubule stabilization and altered neuronal morphology. By using phospho specific antibodies, researchers can track dynamic phosphorylation changes that affect tau function, misfolding, and aggregation. These measurements are essential for understanding how phosphorylation contributes to tau driven pathology.\u003cbr\u003e\u003cbr\u003eIn disease contexts, hyperphosphorylation of tau leads to its detachment from microtubules, promoting aggregation into paired helical filaments and neurofibrillary tangles. These pathological structures disrupt axonal transport and synaptic communication, contributing to cognitive decline in Alzheimer disease and related dementias. Phosphorylation at serine 324 is one of many modifications linked to this process, highlighting the need for site specific detection tools.\u003cbr\u003e\u003cbr\u003eAt the molecular level, tau phosphorylation is regulated by kinases such as GSK3 beta, CDK5, and MAP kinases, as well as phosphatases that reverse the modification. The balance of these enzymes determines tau stability and aggregation propensity. Antibodies against phosphorylated residues such as pS324 enable scientists to monitor this regulatory balance and assess the impact of kinase activity in cellular and animal models.\u003cbr\u003e\u003cbr\u003eThe Phospho Tau antibody pS324 is widely used in western blotting, immunohistochemistry, immunofluorescence, and ELISA to detect site specific phosphorylation. These applications provide insights into disease mechanisms, biomarker discovery, and therapeutic testing. For researchers studying tauopathies, neuronal cytoskeleton regulation, or phosphorylation signaling, this antibody provides a sensitive and specific detection tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Tau - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Tau - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Tau - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Tau - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tau+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047327687021,"sku":"RQ8951","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_df65e94b-7d7b-4129-a7bc-d1262c154c90.jpg?v=1772019451","url":"https:\/\/www.ebiohippo.com\/products\/phospho-tau-antibody-ps324-bha17136369","provider":"BioHippo","version":"1.0","type":"link"}