{"product_id":"phospho-tau-ser202-antibody-mapt-bha17136251","title":"Phospho-Tau (Ser202) Antibody \/ MAPT","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePhospho-Tau (Ser202) Antibody \/ MAPT is a anti-MAPT (phospho-Ser202) Rabbit antibody Recombinant Rabbit Monoclonal clone 31M22 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MAPT (phospho site: Ser202)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31M22, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhospho-Tau (Ser202) antibody detects Tau protein phosphorylated at serine 202, encoded by the MAPT gene. Tau is a microtubule associated protein that stabilizes neuronal microtubules and regulates axonal transport. Phospho-Tau (Ser202) antibody provides researchers with a critical reagent to study neurodegeneration, Alzheimer disease, and tauopathies associated with abnormal Tau phosphorylation.\u003cbr\u003e\u003cbr\u003eTau normally binds and stabilizes microtubules in axons, promoting neuronal structure and intracellular transport. Research using Phospho-Tau (Ser202) antibody has shown that phosphorylation at Ser202 reduces Tau binding to microtubules, leading to destabilization and cytoskeletal disorganization. This modification is an early hallmark of pathological Tau in Alzheimer disease.\u003cbr\u003e\u003cbr\u003eStudies with Phospho-Tau (Ser202) antibody have revealed that hyperphosphorylation at Ser202 and neighboring residues contributes to Tau aggregation into neurofibrillary tangles. These aggregates impair neuronal function and survival, driving neurodegeneration. Detection of Ser202 phosphorylation therefore provides an important marker for disease progression in tauopathies.\u003cbr\u003e\u003cbr\u003eIn Alzheimer disease, Phospho-Tau (Ser202) antibody has demonstrated strong immunoreactivity in affected brain regions such as the hippocampus and cortex. This phosphorylation is mediated by kinases including GSK3 beta and CDK5, linking Tau pathology to signaling pathways dysregulated in disease. Monitoring Ser202 phosphorylation offers insight into how signaling cascades contribute to neuronal dysfunction.\u003cbr\u003e\u003cbr\u003eBeyond Alzheimer disease, Tau phosphorylation at Ser202 is implicated in other neurodegenerative conditions such as progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia. Research using Phospho-Tau (Ser202) antibody has shown that this site is consistently phosphorylated across tauopathies, making it a reliable disease marker.\u003cbr\u003e\u003cbr\u003ePhospho-Tau (Ser202) antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights phosphorylated Tau aggregates in brain tissue, western blotting distinguishes pathological from normal isoforms, and immunofluorescence demonstrates subcellular accumulation in neurons. These approaches make the antibody essential for neurodegeneration research.\u003cbr\u003e\u003cbr\u003eBy supplying validated Phospho-Tau (Ser202) antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eQuantifying post-translational regulation (including phosphorylation) alongside total protein levels.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003ePhospho-site readouts are condition-dependent and are often compared to total target levels when available.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MAPT - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MAPT - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MAPT - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MAPT - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MAPT+review - PhosphoSitePlus search — Cell Signaling Technology — https:\/\/www.phosphosite.org\/search?query=MAPT --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047323230573,"sku":"FY13349","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3d128532-8243-44bc-8cb1-7afa003bd79b.jpg?v=1772019432","url":"https:\/\/www.ebiohippo.com\/products\/phospho-tau-ser202-antibody-mapt-bha17136251","provider":"BioHippo","version":"1.0","type":"link"}