{"product_id":"phyhipl-antibody-phytanoyl-coa-hydroxylase-interacting-protein-like-bha17135556","title":"PHYHIPL Antibody \/ Phytanoyl-CoA hydroxylase-interacting protein-like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePHYHIPL Antibody \/ Phytanoyl-CoA hydroxylase-interacting protein-like is a anti-PHYHIPL Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PHYHIPL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePHYHIPL antibody detects Phytanoyl-CoA hydroxylase-interacting protein-like, a poorly characterized cytoplasmic protein implicated in neuronal signaling and lipid metabolism. Although its precise biochemical function remains under investigation, PHYHIPL is thought to participate in protein-protein interactions related to peroxisomal fatty acid metabolism and neurodevelopmental regulation. The PHYHIPL antibody is used in neuroscience and metabolic studies to explore neuronal protein networks and lipid homeostasis.\u003cbr\u003e\u003cbr\u003ePHYHIPL is encoded by the PHYHIPL gene located on human chromosome 10p12.2. The protein is approximately 148 amino acids long and shows sequence similarity to PHYHIP, which interacts with phytanoyl-CoA hydroxylase, an enzyme involved in alpha-oxidation of branched-chain fatty acids. PHYHIPL is expressed in the brain, liver, and heart, suggesting a broader metabolic role than its paralog.\u003cbr\u003e\u003cbr\u003eThe PHYHIPL antibody detects a 16 kilodalton protein by western blot and displays diffuse cytoplasmic staining under immunofluorescence microscopy. Although the functional data are limited, PHYHIPL has been linked to neuronal differentiation, axonal growth, and synaptic organization through proteomic analyses. It may serve as an adaptor or scaffolding molecule connecting lipid metabolism enzymes with cytoskeletal or signaling components.\u003cbr\u003e\u003cbr\u003eTranscriptomic studies reveal that PHYHIPL expression is enriched in developing neural tissues and reduced in neurodegenerative diseases, indicating potential roles in brain maturation and protection. It has also been identified as a candidate biomarker in studies of metabolic syndromes and cardiovascular disease due to altered expression in lipid-related pathways.\u003cbr\u003e\u003cbr\u003eBecause PHYHIPL likely integrates metabolic and neuronal processes, it serves as a promising research target for understanding how lipid metabolism supports neural function.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PHYHIPL - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PHYHIPL - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PHYHIPL - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PHYHIPL - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PHYHIPL+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047295672685,"sku":"FY12653","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_090a51ad-0720-4720-827f-c55631c73aa8.jpg?v=1782237018","url":"https:\/\/www.ebiohippo.com\/products\/phyhipl-antibody-phytanoyl-coa-hydroxylase-interacting-protein-like-bha17135556","provider":"BioHippo","version":"1.0","type":"link"}