{"product_id":"pias2-polyclonal-antibody-bha11306759","title":"PIAS2 polyclonal antibody","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePrimary Antibody\u003c\/span\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePIAS2 polyclonal antibody\u003c\/strong\u003e is a polyclonal primary antibody raised in Rabbit against PIAS2. It is supplied in unconjugated form. The antibody is documented by Bioworld Technology Inc for use in Western Blot, Immunohistochemistry.\u003c\/p\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eThis gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.\u003c\/p\u003e\n\u003ch2\u003eValidated Applications \u0026amp; Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eValidated Applications\u003c\/th\u003e\n\u003ctd\u003eWestern Blot, Immunohistochemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003ctd\u003eWB,1:500 - 1:2000|IHC,1:50 - 1:200\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePredicted Molecular Weight\u003c\/th\u003e\n\u003ctd\u003e~ 75 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt; 95% (by SDS-PAGE)\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eFormulation \/ Buffer\u003c\/th\u003e\n\u003ctd\u003e1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eUniProt \/ Accession\u003c\/th\u003e\n\u003ctd\u003eO75928\u003c\/td\u003e\n\u003c\/tr\u003e\n\n\u003c\/table\u003e\n\u003ch2\u003eImmunogen \/ Antigen\u003c\/h2\u003e\n\u003cp\u003eRecombinant fusion protein of human PIAS2(NP_004662.2).\u003c\/p\u003e\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003ePolyclonal Antibodies\u003c\/p\u003e\n\u003cp\u003eDocumented species reactivity: Human, Mouse.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-qc-badge\"\u003eQuality control: \u0026gt; 95% (by SDS-PAGE)\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003eThis product is intended \u003cstrong\u003efor research use only (RUO)\u003c\/strong\u003e. It is not intended for use in diagnostic or therapeutic procedures.\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eBrowse additional primary antibodies and immunodetection reagents from Bioworld Technology Inc available through Biohippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Bioworld Technology Inc","offers":[{"title":"50 uL","offer_id":53362391155053,"sku":"BS7196-50UL","price":208.0,"currency_code":"USD","in_stock":true},{"title":"100 uL","offer_id":53362392367469,"sku":"BS7196-100UL","price":358.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BS7196_1.jpg?v=1779482461","url":"https:\/\/www.ebiohippo.com\/products\/pias2-polyclonal-antibody-bha11306759","provider":"BioHippo","version":"1.0","type":"link"}