{"product_id":"pick1-antibody-protein-interacting-with-c-kinase-1-bha17136021","title":"PICK1 Antibody \/ Protein interacting with C kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePICK1 Antibody \/ Protein interacting with C kinase 1 is a anti-PICK1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PICK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePICK1 antibody detects Protein interacting with C kinase 1, a scaffolding protein involved in receptor trafficking, synaptic plasticity, and signal transduction. The UniProt recommended name is Protein interacting with C kinase 1 (PICK1). This adaptor protein binds to protein kinase C (PKC) and various membrane receptors to regulate endocytosis and intracellular transport.\u003cbr\u003e\u003cbr\u003eFunctionally, PICK1 antibody identifies a 415-amino-acid cytoplasmic protein containing a PDZ domain and a BAR domain. The PDZ domain mediates interactions with the C-termini of target proteins such as AMPA-type glutamate receptors, while the BAR domain facilitates membrane curvature sensing and vesicle formation. PICK1 coordinates PKC-dependent receptor internalization and recycling at synapses.\u003cbr\u003e\u003cbr\u003eThe PICK1 gene is located on chromosome 22q13.1 and is widely expressed in brain, testis, and endocrine tissues. In neurons, PICK1 regulates trafficking of AMPA and metabotropic glutamate receptors, influencing long-term synaptic plasticity. It also interacts with ion channels, transporters, and polarity proteins to maintain signal compartmentalization.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of PICK1 contributes to neurological and psychiatric disorders including epilepsy, schizophrenia, and drug addiction. Altered PICK1 expression affects synaptic strength and receptor turnover, disrupting excitatory signaling balance. Research using PICK1 antibody supports studies in synaptic transmission, membrane trafficking, and PKC signaling.\u003cbr\u003e\u003cbr\u003ePICK1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect BAR domain scaffold proteins and synaptic trafficking regulators. \u003cbr\u003e\u003cbr\u003eStructurally, Protein interacting with C kinase 1 features a PDZ domain that binds short peptide motifs on target proteins and a BAR domain that dimerizes to shape membranes. This antibody enables analysis of PICK1's regulatory function in receptor dynamics and neural signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PICK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PICK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PICK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PICK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PICK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312744813,"sku":"FY13119","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_90b5a6fc-da2b-4093-b37a-b82c1fe62865.jpg?v=1782237092","url":"https:\/\/www.ebiohippo.com\/products\/pick1-antibody-protein-interacting-with-c-kinase-1-bha17136021","provider":"BioHippo","version":"1.0","type":"link"}