{"product_id":"piezo2-antibody-fam38b-bha17128177","title":"PIEZO2 Antibody \/ FAM38B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003ePIEZO2 Antibody \/ FAM38B is an antibody targeting \u003cstrong\u003eFAM38B\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FAM38B.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003ePIEZO2 (Piezo-type mechanosensitive ion channel component 2), also called Protein FAM38B, is a transmembrane protein that spans the cell membrane and acts as a sensor for mechanical stimuli. When external forces, such as touch or pressure, are applied to the cell membrane, PIEZO2 responds by opening up and allowing ions to flow into the cell. This influx of ions triggers a signal that is transmitted to the brain, allowing us to perceive and respond to the touch sensation. It also plays a critical role in a variety of other sensory functions, including proprioception (the ability to sense the position of our body in space) and hearing. Recent studies have uncovered even more functions of PIEZO2 beyond sensory perception. It has been found to be involved in regulating lung development, bone formation, and even cell migration.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q9H5I5 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q9H5I5 - Gene search: FAM38B — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FAM38B - Ensembl search: FAM38B — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FAM38B - PubMed search: FAM38B antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FAM38B+antibody - Reactome search: FAM38B — Reactome — https:\/\/reactome.org\/content\/query?q=FAM38B --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046411231597,"sku":"F55114-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046472212845,"sku":"F55114-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_877d6c0b-d184-4438-b44b-a4d64e7ab7cf.jpg?v=1772000491","url":"https:\/\/www.ebiohippo.com\/products\/piezo2-antibody-fam38b-bha17128177","provider":"BioHippo","version":"1.0","type":"link"}