{"product_id":"pik3c2a-antibody-phosphoinositide-3-kinase-c2-alpha-bha17135720","title":"PIK3C2A Antibody \/ Phosphoinositide 3-kinase-C2-alpha","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePIK3C2A Antibody \/ Phosphoinositide 3-kinase-C2-alpha is a anti-PIK3C2A Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse. Reported localization: Cytoplasm, Nucleus, Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PIK3C2A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePIK3C2A antibody detects Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, a lipid kinase that regulates membrane trafficking, signal transduction, and cytoskeletal organization. Encoded by the PIK3C2A gene on chromosome 11p15.5, this enzyme belongs to the class II phosphoinositide 3-kinase (PI3K) family and phosphorylates phosphatidylinositol and phosphatidylinositol 4-phosphate to generate phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). Through these lipid intermediates, PIK3C2A coordinates endocytosis, vesicle trafficking, and cell polarity regulation.\u003cbr\u003e\u003cbr\u003ePIK3C2A contains a catalytic kinase domain, a C2 lipid-binding domain, and clathrin-binding regions that localize it to the plasma membrane and endosomes. Its enzymatic activity is essential for clathrin-mediated endocytosis and autophagosome formation. PIK3C2A also modulates signaling pathways downstream of receptor tyrosine kinases and integrins by influencing AKT activation and cytoskeletal reorganization.\u003cbr\u003e\u003cbr\u003eThe PIK3C2A antibody is widely used in cell signaling, membrane biology, and cancer research to study phosphoinositide metabolism, vesicle formation, and kinase regulation. Western blot analysis identifies a 180-190 kilodalton band corresponding to PIK3C2A, while immunofluorescence reveals punctate staining in endosomal and plasma membrane compartments. This antibody enables the analysis of lipid signaling networks that control intracellular transport and cellular morphology.\u003cbr\u003e\u003cbr\u003eLoss or mutation of PIK3C2A has been linked to congenital cataracts, vascular defects, and impaired cilia formation due to disrupted membrane trafficking. Conversely, overexpression contributes to tumorigenesis through altered PI3K signaling and enhanced migration. The PIK3C2A antibody provides a robust tool for investigating lipid kinase function in physiology and disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PIK3C2A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PIK3C2A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PIK3C2A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PIK3C2A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PIK3C2A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047302881645,"sku":"FY12818","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_74ca6ba8-e5b2-4a64-8216-d771fc11001b.jpg?v=1782237036","url":"https:\/\/www.ebiohippo.com\/products\/pik3c2a-antibody-phosphoinositide-3-kinase-c2-alpha-bha17135720","provider":"BioHippo","version":"1.0","type":"link"}