{"product_id":"pik3ca-antibody-bha11909895","title":"PIK3CA Antibody","description":"\u003cp\u003ePIK3CA encodes the catalytic subunit p110α of phosphoinositide 3-kinase (PI3K), a central component of the PI3K\/AKT\/mTOR signaling pathway. This pathway is essential for regulating cell growth, metabolism, survival, and synaptic plasticity in the nervous system. While PIK3CA is well-characterized in oncology, its emerging role in neurodegenerative disease is gaining increasing attention.\u003c\/p\u003e\n\n\u003cp\u003eIn neurons, PIK3CA activity supports axonal growth, dendritic arborization, and resistance to oxidative stress. Dysregulation of PI3K signaling—whether through genetic mutations, altered expression, or upstream receptor dysfunction—can impair neuronal survival and contribute to synaptic degeneration. In Alzheimer’s disease, reduced PI3K\/AKT signaling is associated with increased tau phosphorylation, amyloid-beta toxicity, and impaired autophagy. Conversely, hyperactivation of this pathway has been linked to aberrant protein synthesis and neurodevelopmental disorders.\u003c\/p\u003e\n\n\u003cp\u003ePIK3CA also modulates neuroinflammatory responses by influencing microglial activation and cytokine production. Its role in maintaining blood-brain barrier integrity and regulating neuronal-glial interactions further underscores its relevance in neurodegenerative pathology.\u003c\/p\u003e\n\n\u003cp\u003eTherapeutic strategies targeting PIK3CA and its downstream effectors are being explored to restore cellular homeostasis, enhance neuroprotection, and slow disease progression. As a master regulator of neuronal resilience, PIK3CA represents a promising biomarker and intervention point in the treatment of neurodegenerative diseases.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040794632557,"sku":"SPC-741D","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040888283501,"sku":"SPC-741D-A390","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040888316269,"sku":"SPC-741D-A488","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040888349037,"sku":"SPC-741D-A594","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040888381805,"sku":"SPC-741D-APC","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040888414573,"sku":"SPC-741D-BI","price":386.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040888447341,"sku":"SPC-741D-FITC","price":381.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040888480109,"sku":"SPC-741D-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040888512877,"sku":"SPC-741D-PCP","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040888545645,"sku":"SPC-741D-RPE","price":388.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040888578413,"sku":"SPC-741S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-741_PIK3CA_Antibody_WB_Mouse_brain-lysate_1.png?v=1771832164","url":"https:\/\/www.ebiohippo.com\/products\/pik3ca-antibody-bha11909895","provider":"BioHippo","version":"1.0","type":"link"}