{"product_id":"pitpnc1-antibody-phosphatidylinositol-transfer-protein-cytoplasmic-1-bha17135310","title":"PITPNC1 Antibody \/ Phosphatidylinositol transfer protein cytoplasmic 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePITPNC1 Antibody \/ Phosphatidylinositol transfer protein cytoplasmic 1 is a anti-PITPNC1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PITPNC1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe PITPNC1 antibody targets Phosphatidylinositol transfer protein, cytoplasmic 1, an intracellular lipid-binding protein encoded by the PITPNC1 gene. This protein regulates phosphoinositide signaling and lipid transport between membrane compartments. Phosphatidylinositol transfer protein, cytoplasmic 1 contributes to Golgi function, vesicular trafficking, and lipid-mediated signaling cascades. The PITPNC1 antibody enables specific detection of this protein in studies exploring cell signaling, membrane dynamics, and cancer metastasis.\u003cbr\u003e\u003cbr\u003ePhosphatidylinositol transfer protein, cytoplasmic 1 binds phosphatidylinositol (PI) and phosphatidic acid (PA) and facilitates lipid exchange between Golgi and plasma membranes. It helps maintain phosphoinositide composition essential for vesicle budding and membrane identity. The PITPNC1 antibody supports localization studies revealing its enrichment at Golgi membranes and cytoplasmic vesicles. Through regulation of phosphoinositide pools, PITPNC1 coordinates signaling events that control secretion and membrane remodeling.\u003cbr\u003e\u003cbr\u003eRecent research has shown that elevated PITPNC1 expression enhances tumor cell secretion and metastasis by increasing Golgi activity and secretion of pro-invasive factors such as MMP1 and HTRA1. The PITPNC1 antibody is a crucial reagent for investigating these mechanisms and assessing protein levels in metastatic cancer tissues. Its detection enables evaluation of how lipid signaling supports tumor cell migration and invasion through altered vesicle trafficking.\u003cbr\u003e\u003cbr\u003ePhosphatidylinositol transfer protein, cytoplasmic 1 also functions in insulin secretion and lipid homeostasis, highlighting its importance beyond oncology. The PITPNC1 antibody supports studies into these metabolic processes by enabling detection in endocrine cells and liver tissues. Altered PITPNC1 expression may influence lipid droplet formation and phosphatidylinositol-dependent signaling in metabolic diseases.\u003cbr\u003e\u003cbr\u003eThe PITPNC1 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, providing characteristic Golgi-associated staining.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PITPNC1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PITPNC1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PITPNC1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PITPNC1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PITPNC1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286169965,"sku":"FY12407","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6a95dbbf-6c49-4a05-9d09-fba51fcc0b46.jpg?v=1782236989","url":"https:\/\/www.ebiohippo.com\/products\/pitpnc1-antibody-phosphatidylinositol-transfer-protein-cytoplasmic-1-bha17135310","provider":"BioHippo","version":"1.0","type":"link"}