{"product_id":"plekhb1-antibody-pleckstrin-homology-domain-containing-family-b-member-1-bha17136272","title":"PLEKHB1 Antibody \/ Pleckstrin homology domain-containing family B member 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePLEKHB1 Antibody \/ Pleckstrin homology domain-containing family B member 1 is a anti-PLEKHB1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Monkey, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PLEKHB1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePLEKHB1 antibody detects Pleckstrin homology domain-containing family B member 1, a membrane-associated protein encoded by the PLEKHB1 gene on chromosome 11p15.1. PLEKHB1 contains a pleckstrin homology (PH) domain and is involved in maintaining plasma membrane structure, vesicular trafficking, and cell signaling. It is expressed in the retina, brain, and epithelial tissues, where it contributes to cell polarity and intracellular transport. PLEKHB1 is particularly enriched in photoreceptor cells and neuronal synapses, supporting visual signal transmission and neuronal membrane organization.\u003cbr\u003e\u003cbr\u003eStructurally, PLEKHB1 contains a conserved PH domain that binds phosphatidylinositol lipids, anchoring the protein to the inner leaflet of the plasma membrane. It also possesses regions that mediate protein-protein interactions with cytoskeletal and vesicular trafficking partners. PLEKHB1 belongs to the pleckstrin homology domain-containing protein family, which includes PLEKHB2, and participates in membrane dynamics and receptor recycling. Co-localization studies show PLEKHB1 distributed along synaptic membranes and photoreceptor outer segments.\u003cbr\u003e\u003cbr\u003eFunctionally, PLEKHB1 plays an important role in synaptic vesicle trafficking and receptor localization. In the retina, it interacts with proteins such as syntaxin and SNAP25 to regulate photoreceptor membrane stability and neurotransmitter release. In neurons, it supports axonal transport and signal transduction by organizing lipid domains within the plasma membrane. PLEKHB1 may also contribute to cellular polarity through coordination of phosphoinositide signaling at the membrane. During development, PLEKHB1 expression coincides with neural and retinal differentiation.\u003cbr\u003e\u003cbr\u003eDysregulation or mutation of PLEKHB1 has been linked to inherited retinal degenerations and neurological disorders. Its loss disrupts photoreceptor membrane architecture, leading to vision impairment. In cancer biology, PLEKHB1 expression patterns have been used as markers of epithelial polarity and tumor differentiation. Pathway associations include membrane trafficking, phosphatidylinositol signaling, and synaptic vesicle exocytosis. Co-localization with other PH domain proteins suggests a conserved role in regulating membrane-associated signaling complexes.\u003cbr\u003e\u003cbr\u003eThe PLEKHB1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PLEKHB1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PLEKHB1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PLEKHB1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PLEKHB1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PLEKHB1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047323492717,"sku":"FY13370","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9f45425a-5284-4fc8-98b3-4d4349438b28.jpg?v=1782237113","url":"https:\/\/www.ebiohippo.com\/products\/plekhb1-antibody-pleckstrin-homology-domain-containing-family-b-member-1-bha17136272","provider":"BioHippo","version":"1.0","type":"link"}