{"product_id":"positive-mk-801-maleate-bhb21300223","title":"(+)-MK 801 maleate","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Dizocilpine hydrogen maleate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 77086-22-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C20H19NO4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.01-10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NMDA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e (+)-MK 801 maleate is a potent, selective and non-competitive NMDA receptor antagonist with an IC50 of 0.01 μM1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Dizocilpine hydrogen maleate\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eMK-801 maleate is a non competitive, high affinity, open channel blocker of the N-methyl-D-aspartate (NMDA) receptors. MK-801 blocks NMDA-induced currents in a voltage-dependent manner, preventing the influx of calcium ions through the channel. This compound is being used as a pharmacological tool to explore NMDA receptor function.The drug exists in two isomers (+) and (-) and displays several biological properties such as anticonvulsant and anesthetic. MK-801 is not used clinically because it has been shown to promote the development of brain lesions in rats1,2.NMDA receptors are ion channels gated by the major excitatory neurotransmitter in the mammalian central nervous system, glutamate. Glutamate-mediated signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception3.In rats, MK-801 has the ability to induce a characteristic behavioral syndrome with ataxia, stereotypic behavior and hyperlocomotion. In addition, the compound can induce necrosis in a small population of neurons in the cortex of rats4.It has also been discerned that MK-801 induces schizophrenia-like symptoms in rodents, including cognitive functions5.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249711014253,"sku":"M-230-10MG-1","price":57.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311566479725,"sku":"M-230-100MG-1","price":401.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311566512493,"sku":"M-230-25MG-1","price":124.0,"currency_code":"USD","in_stock":true},{"title":"250 mg \/ 1","offer_id":53311566545261,"sku":"M-230-250MG-1","price":950.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311566578029,"sku":"M-230-5MG-1","price":46.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311566610797,"sku":"M-230-50MG-1","price":221.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/M-230_gr-1.gif?v=1778544437","url":"https:\/\/www.ebiohippo.com\/products\/positive-mk-801-maleate-bhb21300223","provider":"BioHippo","version":"1.0","type":"link"}