{"product_id":"primary-small-airway-epithelial-cells-negative-copd-bhc10902216","title":"Primary Small Airway Epithelial Cells - COPD","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThese primary Small Airway Epithelial Cells (COPD) are derived from the small airway epithelium of a COPD patient. These cells are suitable for studying COPD mechanisms, evaluating new drugs, understanding small airway remodeling, and investigating the disease's progression at a cellular level, particularly in the smaller airways where critical changes occur in COPD. The product is supplied as frozen cells.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological source:\u003c\/strong\u003e Human (H. sapiens)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue origin:\u003c\/strong\u003e Airway\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth properties:\u003c\/strong\u003e Adherent, packed cuboidal\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Frozen\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReported expression\/markers:\u003c\/strong\u003e Pan-Cytokeratin (+), TE-7 (-)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDonor history:\u003c\/strong\u003e Not disclosed\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiosafety level:\u003c\/strong\u003e II\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eEpithelial cells form polarized barriers that regulate transport, secretion, and defense at tissue interfaces. Their phenotype is shaped by cell polarity, junctional organization, and tissue-specific differentiation cues.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003ePrimary epithelial models are widely used to examine barrier integrity, cytokine responses, and transport processes under physiologic conditions.\u003c\/li\u003e\n\u003cli\u003eResearchers often combine epithelial cells with stromal or immune components to model tissue microenvironments more faithfully.\u003c\/li\u003e\n\u003cli\u003eDonor-matched or disease-context epithelial cells help capture inter-individual heterogeneity in response assays.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eMeasure barrier integrity, junctional organization, and polarized responses in vitro.\u003c\/li\u003e\n\u003cli\u003eEvaluate cytokine, pathogen, or drug responses in tissue-relevant epithelial cultures.\u003c\/li\u003e\n\u003cli\u003eUse in co-culture or air-liquid interface-adjacent workflows when epithelial context matters.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eProduct-specific data supplied for this listing\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eGrowth Conditions:\u003c\/strong\u003e For optimal cell culture, we recommend using PriCoat™ T25 Flasks (G299) or coating your preferred vessels with Applied Cell Extracellular Matrix (G422) , PriGrow X Series Medium for T4142 (TM4142) + 1% Penicillin\/Streptomycin Solution (G255), 37.0°C, 5% CO₂.\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003ePrimary cells can show donor-dependent and passage-dependent variation, so morphology, growth rate, and marker expression should be interpreted in the context of the specific lot and culture history.\u003c\/li\u003e\n\u003cli\u003eAttachment matrix, medium formulation, and gas conditions can materially influence phenotype maintenance and experimental readouts; use the recommended culture system where possible.\u003c\/li\u003e\n\u003cli\u003eCryopreserved recovery conditions matter for viability and downstream behavior. We recommend using serum-free CryoGuard™ Freezing Media (TM078).\u003c\/li\u003e\n\u003cli\u003eMarker panels should be interpreted together with morphology and functional readouts rather than as a standalone identity measure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"display:none\"\u003eSKU:BHC10902216\u003c\/p\u003e","brand":"Applied Biological Materials (abm) Inc.","offers":[{"title":"5x10\u003csup\u003e5\u003c\/sup\u003e cells \/ 1.0 ml","offer_id":53195756962157,"sku":"T4142","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NMMzVJFaoMamhBRn3APPLE8FTKkYYFEm4jt2par1.png?v=1775322491","url":"https:\/\/www.ebiohippo.com\/products\/primary-small-airway-epithelial-cells-negative-copd-bhc10902216","provider":"BioHippo","version":"1.0","type":"link"}