{"product_id":"prmt7-antibody-protein-arginine-methyltransferase-7-bha17135682","title":"PRMT7 Antibody \/ Protein arginine methyltransferase 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePRMT7 Antibody \/ Protein arginine methyltransferase 7 is a anti-PRMT7 Rabbit antibody Recombinant Rabbit Monoclonal clone 29P93 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PRMT7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29P93, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePRMT7 antibody detects protein arginine methyltransferase 7, encoded by the PRMT7 gene. This enzyme is also known as HRMT1L2, HMT7, and protein arginine N methyltransferase 7. PRMT7 belongs to the PRMT family, which catalyzes the methylation of arginine residues on histones and non histone proteins. Unlike most PRMTs that catalyze asymmetric dimethylation, PRMT7 is unique in generating symmetric dimethylarginine. This modification regulates chromatin structure, transcription, RNA processing, and signal transduction. PRMT7 localizes to the nucleus and cytoplasm, where it modifies diverse protein substrates.\u003cbr\u003e\u003cbr\u003ePRMT7 antibody is widely applied in epigenetics, RNA biology, and cancer research. By detecting PRMT7, researchers can explore how symmetric arginine dimethylation influences chromatin regulation and cellular signaling. PRMT7 activity has been linked to stem cell pluripotency, DNA repair, stress responses, and immune regulation. In embryonic stem cells, PRMT7 maintains self renewal by repressing differentiation associated genes. In DNA repair, PRMT7 modifies proteins such as histone H4, contributing to recruitment of repair complexes.\u003cbr\u003e\u003cbr\u003eApplications of PRMT7 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects PRMT7 protein in nuclear and cytoplasmic fractions, immunohistochemistry maps expression in tissues such as testis and skeletal muscle, and immunofluorescence highlights dynamic localization in response to stress. These assays provide powerful approaches for analyzing PRMT7 biology across systems.\u003cbr\u003e\u003cbr\u003ePRMT7 dysregulation contributes to cancer, immune dysfunction, and developmental syndromes. Amplification or overexpression of PRMT7 has been observed in breast, lung, and hematologic cancers, where it alters gene expression and promotes survival. Loss of PRMT7 function has been associated with intellectual disability syndromes, reflecting its role in neural development. By applying PRMT7 antibody, scientists can investigate how balanced methyltransferase activity is required for normal physiology.\u003cbr\u003e\u003cbr\u003eTherapeutically, PRMT7 is a candidate drug target. Inhibitors of PRMT7 are under development to modulate arginine methylation in cancer and immune diseases. Detection of PRMT7 expression by antibody based assays provides biomarkers for preclinical studies and therapeutic development.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PRMT7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PRMT7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PRMT7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PRMT7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PRMT7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047299932525,"sku":"FY12779","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4ff20e16-7567-428e-8c7c-88c1609f17bf.jpg?v=1772019340","url":"https:\/\/www.ebiohippo.com\/products\/prmt7-antibody-protein-arginine-methyltransferase-7-bha17135682","provider":"BioHippo","version":"1.0","type":"link"}