{"product_id":"propionyl-coenzyme-a-sodium-salt-bhb21200008","title":"Propionyl Coenzyme A, Sodium salt","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003ePropionyl Coenzyme A, Sodium salt is a biochemical supplied by Coenza for use in enzymology and metabolic research. Available as Lyophilized powder, purity ≥ 95%, suitable for in vitro assays and pathway studies.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso known as:\u003c\/em\u003e 03:0 Coenzyme A.\u003c\/p\u003e\n\u003ch2\u003eKey Elements and Design Rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula \/ MW \/ Purity:\u003c\/strong\u003e C24H37N7O17P3S · xNa; 823.14 g\/mol (free acid basis); ≥ 95%. The Sodium salt form provides enhanced aqueous stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm \/ Solubility:\u003c\/strong\u003e Lyophilized powder; Soluble in water.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 03:0 Coenzyme A.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Synthetic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003ePropanoyl Coenzyme A (Propanoyl-CoA), also known as propionyl-CoA, is a three-carbon thioester derivative of Coenzyme A that plays a crucial role in intermediary metabolism. It is formed during the catabolism of odd-chain fatty acids, certain amino acids (such as valine, isoleucine, and methionine), and cholesterol. Propanoyl-CoA serves as an intermediate in the conversion of propionate to succinyl-CoA, a key metabolite in the tricarboxylic acid (TCA) cycle. This pathway is vital for energy production and the gluconeogenic process, linking lipid and carbohydrate metabolism in cells (Horswill \u0026amp; Escalante-Semerena, 1999; Luo et al., 2016).ApplicationsPropanoyl Coenzyme A, Sodium Salt, is commonly used in biochemical and metabolic research to study enzyme activities and metabolic pathways involving short-chain fatty acids. It is particularly valuable for investigating the metabolism of odd-chain fatty acids, amino acid degradation, and their integration into the TCA cycle. Researchers use Propanoyl-CoA Sodium Salt in vitro to analyze metabolic flux, study enzyme kinetics, and understand the regulatory mechanisms of CoA derivatives under normal and pathological conditions (Horswill \u0026amp; E\u003c\/p\u003e\n\u003ch2\u003eResearch Relevance and Current Trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcyl-CoA metabolism increasingly linked to histone acylation marks and epigenetic regulation in cancer and metabolic disease research.\u003c\/li\u003e\n\u003cli\u003eGrowing interest in short-chain fatty acid CoA thioesters as mediators of gut microbiome–host metabolic crosstalk.\u003c\/li\u003e\n\u003cli\u003eCoA-dependent enzymes investigated as drug targets in infectious disease and neurometabolic disorder research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon Research Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnzyme kinetics assays — direct substrate for acyltransferases, thiolases, and dehydrogenases.\u003c\/li\u003e\n\u003cli\u003eMetabolic flux analysis — isotope-labeled variants available for stable-isotope tracing.\u003c\/li\u003e\n\u003cli\u003eIn vitro pathway reconstitution for fatty acid β-oxidation, TCA cycle, or polyketide biosynthesis.\u003c\/li\u003e\n\u003cli\u003eBiochemical characterization of CoA-binding proteins by activity assays or binding measurements.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eNotes for Experimental Interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCoA thioesters hydrolyze at neutral–alkaline pH; prepare working solutions fresh and keep on ice.\u003c\/li\u003e\n\u003cli\u003eDifferent salt forms share the same core structure — normalize concentrations using the free-acid MW when comparing across forms.\u003c\/li\u003e\n\u003cli\u003eThiol oxidation may occur upon air exposure; use under inert atmosphere or with reducing agents where appropriate.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Coenza","offers":[{"title":"10 mg","offer_id":53249726972269,"sku":"A-09-10MG","price":363.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fc74bc_494aad7c39c44902a6d101cb239499de_mv2.png?v=1776855585","url":"https:\/\/www.ebiohippo.com\/products\/propionyl-coenzyme-a-sodium-salt-bhb21200008","provider":"BioHippo","version":"1.0","type":"link"}