{"product_id":"psmb10-antibody-proteasome-subunit-beta-type-10-bha17135512","title":"PSMB10 Antibody \/ Proteasome subunit beta type-10","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePSMB10 Antibody \/ Proteasome subunit beta type-10 is a anti-PSMB10 Rabbit antibody Recombinant Rabbit Monoclonal clone 30P41 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PSMB10\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30P41, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePSMB10 antibody detects proteasome subunit beta type-10, an essential catalytic component of the immunoproteasome encoded by the PSMB10 gene. PSMB10, also called LMP10 or MECL-1, belongs to the peptidase T1 family and contributes to antigen processing for major histocompatibility complex class I presentation. By replacing constitutive catalytic subunits in the proteasome, PSMB10 alters proteolytic specificity, optimizing generation of peptides suitable for immune recognition.\u003cbr\u003e\u003cbr\u003ePSMB10 antibody is widely applied in immunology, cancer biology, and infection research. The immunoproteasome is induced by interferon gamma and is enriched in immune tissues such as lymph nodes and spleen. Detection of PSMB10 provides insight into immune activation, antigen presentation, and adaptive immune responses. By monitoring PSMB10 expression, researchers can explore how immunoproteasome activity contributes to pathogen clearance and tumor surveillance.\u003cbr\u003e\u003cbr\u003e Western blot assays identify PSMB10 protein bands in interferon-stimulated cells, while immunohistochemistry maps expression in lymphoid tissues. Immunofluorescence highlights cytoplasmic distribution within proteasome complexes. These applications make PSMB10 antibody a valuable tool for studying immune regulation.\u003cbr\u003e\u003cbr\u003ePSMB10 has clinical significance in autoimmune disease, cancer, and viral infection. Dysregulated immunoproteasome activity alters antigen presentation, contributing to autoimmunity and chronic inflammation. Elevated PSMB10 expression has been linked to tumor immune evasion and therapy resistance. By applying PSMB10 antibody, scientists can investigate how immunoproteasome function affects immunity and pathology.\u003cbr\u003e\u003cbr\u003ePSMB10 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PSMB10 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PSMB10 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PSMB10 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PSMB10 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PSMB10+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047294263661,"sku":"FY12609","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0374d7e4-f060-4933-8280-b1f24f4778f9.jpg?v=1772019317","url":"https:\/\/www.ebiohippo.com\/products\/psmb10-antibody-proteasome-subunit-beta-type-10-bha17135512","provider":"BioHippo","version":"1.0","type":"link"}