{"product_id":"ptk2b-antibody-pyk2-protein-tyrosine-kinase-2-beta-bha17135831","title":"PTK2B Antibody \/ PYK2 \/ Protein tyrosine kinase 2 beta","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePTK2B Antibody \/ PYK2 \/ Protein tyrosine kinase 2 beta is a anti-PTK2B Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PTK2B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePTK2B antibody detects Protein tyrosine kinase 2 beta, also known as PYK2, a non-receptor tyrosine kinase involved in calcium-dependent signal transduction, cytoskeletal remodeling, and synaptic plasticity. Encoded by the PTK2B gene on chromosome 8p21.2, PYK2 belongs to the focal adhesion kinase (FAK) family and mediates signals downstream of G-protein-coupled receptors, integrins, and ion channels. It is abundantly expressed in brain, immune cells, and epithelial tissues, where it regulates adhesion, migration, and intracellular calcium responses.\u003cbr\u003e\u003cbr\u003eStructurally, PYK2 is a 1,009-amino-acid cytoplasmic protein of approximately 116 kilodaltons containing an N-terminal FERM domain for membrane association, a central kinase domain, and a C-terminal focal adhesion-targeting (FAT) domain. Activation occurs through autophosphorylation at tyrosine 402, creating a binding site for Src family kinases and downstream effectors. The protein localizes to focal adhesions and postsynaptic densities, linking calcium signals to cytoskeletal dynamics and synaptic strength.\u003cbr\u003e\u003cbr\u003eThe PTK2B antibody is widely used in neuroscience, immunology, and cancer biology research to study focal adhesion signaling, neuronal activity, and cell migration. Western blot analysis detects a 116 kilodalton band corresponding to PYK2, while immunofluorescence shows punctate cytoplasmic and perinuclear staining consistent with activated signaling foci. This antibody enables exploration of calcium-sensitive kinase pathways and their contribution to cell communication and motility.\u003cbr\u003e\u003cbr\u003eFunctionally, PYK2 mediates integrin and calcium-dependent signaling that regulates cytoskeletal rearrangement, vesicle trafficking, and neuronal transmission. In the nervous system, PYK2 modulates synaptic plasticity and learning, while in immune cells it controls adhesion and migration. Dysregulation of PTK2B expression or activity has been linked to Alzheimer's disease, inflammatory disorders, and cancer metastasis. The PTK2B antibody provides a versatile reagent for investigating kinase activation, intracellular signaling dynamics, and calcium-dependent regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PTK2B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PTK2B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PTK2B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PTK2B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PTK2B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306584429,"sku":"FY12929","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_870dc866-eb1f-4b0e-a245-f54c37bf46a9.jpg?v=1782237057","url":"https:\/\/www.ebiohippo.com\/products\/ptk2b-antibody-pyk2-protein-tyrosine-kinase-2-beta-bha17135831","provider":"BioHippo","version":"1.0","type":"link"}