{"product_id":"pvalb-antibody-parvalbumin-bha17136309","title":"PVALB Antibody \/ Parvalbumin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePVALB Antibody \/ Parvalbumin is a anti-PVALB Rabbit antibody Recombinant Rabbit Monoclonal clone AOFB-16 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human, Mouse, Rat. Reported localization: Nucleus, Cytoplasm, Cell junctions.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PVALB\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone AOFB-16, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eParvalbumin (PVALB) is a small calcium-binding protein belonging to the EF-hand superfamily. It is highly expressed in fast-twitch muscle fibers and specific populations of neurons, where it contributes to rapid calcium buffering and relaxation processes. In the nervous system, PVALB is a well-established marker for certain GABAergic interneurons.    \u003cp\u003ePVALB plays a role in regulating intracellular calcium signaling, influencing muscle contraction dynamics and neuronal excitability. Altered PVALB expression has been associated with neurological conditions, including epilepsy and neurodevelopmental disorders. It is also widely studied in neuroanatomical mapping and muscle physiology research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality PVALB antibody enables precise detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A PVALB antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PVALB - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PVALB - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PVALB - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PVALB - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PVALB+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325393261,"sku":"RQ8890","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_82724bd0-8187-43b2-913a-c5c420f6bca1.jpg?v=1772019442","url":"https:\/\/www.ebiohippo.com\/products\/pvalb-antibody-parvalbumin-bha17136309","provider":"BioHippo","version":"1.0","type":"link"}