{"product_id":"qrich1-antibody-glutamine-rich-protein-1-bha17135383","title":"QRICH1 Antibody \/ Glutamine-rich protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eQRICH1 Antibody \/ Glutamine-rich protein 1 is a anti-QRICH1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e QRICH1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eQRICH1 antibody recognizes Glutamine-rich protein 1, a stress-responsive transcriptional regulator involved in the unfolded protein response, apoptosis, and cell differentiation. QRICH1 serves as a key mediator of endoplasmic reticulum (ER) stress adaptation by modulating gene expression in response to misfolded protein accumulation. The QRICH1 antibody is widely used in studies of ER stress signaling, apoptosis regulation, and differentiation processes that depend on transcriptional stress sensors.\u003cbr\u003e\u003cbr\u003eQRICH1 is encoded by the QRICH1 gene located on human chromosome 3q13.33. The protein is approximately 71 kilodaltons and characterized by an N-terminal glutamine-rich region that supports transcriptional activation and protein-protein interactions. QRICH1 functions downstream of the PERK-eIF2-alpha pathway during the integrated stress response. Under ER stress, phosphorylation of eIF2-alpha suppresses general translation but selectively promotes QRICH1 translation, leading to activation of genes involved in protein folding, lipid metabolism, and apoptosis suppression.\u003cbr\u003e\u003cbr\u003eThe QRICH1 antibody enables detection of the protein by western blot, where it typically appears as a band around 86-100 kilodaltons. Immunofluorescence and confocal microscopy reveal predominant nuclear localization, consistent with its role as a transcriptional regulator. QRICH1 cooperates with transcriptional coactivators to regulate stress-responsive promoters and contributes to reprogramming during differentiation of osteoblasts, neurons, and epithelial cells. Knockdown experiments demonstrate that QRICH1 deficiency enhances sensitivity to ER stress-induced apoptosis, whereas overexpression supports cell survival by restoring proteostasis.\u003cbr\u003e\u003cbr\u003eRecent studies link QRICH1 to human skeletal dysplasia, where loss-of-function mutations impair osteoblast differentiation and bone matrix formation. Additionally, QRICH1 modulates lipid homeostasis and is involved in metabolic regulation under nutrient stress. It may also influence viral infection responses through control of translation reinitiation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=QRICH1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=QRICH1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=QRICH1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/QRICH1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=QRICH1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047289512301,"sku":"FY12480","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a2258cf5-3ac4-4f11-be51-e291aec9d0cc.jpg?v=1782237007","url":"https:\/\/www.ebiohippo.com\/products\/qrich1-antibody-glutamine-rich-protein-1-bha17135383","provider":"BioHippo","version":"1.0","type":"link"}