{"product_id":"qtrt2-antibody-queuine-trna-ribosyltransferase-subunit-2-bha17135216","title":"QTRT2 Antibody \/ Queuine tRNA-ribosyltransferase subunit 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eQTRT2 Antibody \/ Queuine tRNA-ribosyltransferase subunit 2 is a anti-QTRT2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e QTRT2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eQTRT2 antibody detects Queuine tRNA-ribosyltransferase subunit 2, encoded by the QTRT2 gene on chromosome 6p25.1. QTRT2 antibody is widely used in RNA modification, translation, and metabolism research. QTRT2 partners with QTRT1 to form the heterodimeric tRNA-guanine transglycosylase complex that catalyzes incorporation of queuine into the anticodon wobble position of tRNAs. This modification enhances translation accuracy and efficiency.\u003cbr\u003e\u003cbr\u003eStructurally, QTRT2 is a ~47 kDa protein that shares homology with QTRT1 but lacks catalytic residues. Instead, QTRT2 functions as a structural subunit that stabilizes the heterodimer and facilitates substrate recognition. QTRT2 localizes to the cytoplasm where tRNA modification occurs. It is conserved across eukaryotes, reflecting its fundamental role in translation regulation.\u003cbr\u003e\u003cbr\u003eFunctionally, QTRT2 supports tRNA modification that improves translational fidelity and codon-anticodon interactions. Queuine modification affects protein synthesis rates, cellular stress responses, and adaptation to nutrient availability. Researchers use QTRT2 antibody to investigate RNA modifications, translation quality control, and metabolic regulation.\u003cbr\u003e\u003cbr\u003eClinically, defects in queuine modification have been associated with cancer, neurodevelopmental disorders, and infection. Altered expression of QTRT2 has been reported in some tumors, suggesting a role in metabolic reprogramming and growth. Because RNA modifications are emerging therapeutic targets, QTRT2 is under active investigation. \u003cbr\u003e\u003cbr\u003eExperimentally, QTRT2 antibody is applied in western blotting to detect the ~47 kDa protein, in immunofluorescence microscopy to study cytoplasmic localization, and in immunoprecipitation to analyze QTRT1-QTRT2 complexes. Functional assays combining QTRT2 antibody with RNA analysis confirm its role in tRNA modification.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=QTRT2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=QTRT2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=QTRT2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/QTRT2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=QTRT2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285383533,"sku":"FY12313","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_22fb6db5-9523-413c-ac36-d8b94d633a99.jpg?v=1782236983","url":"https:\/\/www.ebiohippo.com\/products\/qtrt2-antibody-queuine-trna-ribosyltransferase-subunit-2-bha17135216","provider":"BioHippo","version":"1.0","type":"link"}