{"product_id":"raav-cag-egfp-5-mir-30-shrna-scramble-3-mir-30-wpre-3xmir122a-polya-bhv12401205","title":"AAV-CAG-EGFP-5'miR-30-shRNA(scramble)-3'miR-30-WPRE-3XmiR122a-polyA","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports gene silencing approaches (e.g., RNAi-based knockdown) for functional studies where partial reduction is sufficient or preferred. Silencing constructs can be advantageous when complete knockout is lethal or causes compensatory effects.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eKnockdown efficiency depends on target sequence choice, expression level, and cell-type context. Validation typically combines mRNA\/protein measurements with functional readouts.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by a promoter choice that shapes cell-type bias and expression strength; CAG promoter, a strong hybrid promoter that supports robust expression across many cell types. The expression design includes regulatory elements that can constrain activity to specific genetic contexts or experimental conditions. A built-in reporter\/tag supports validation and localization; GFP\/EGFP provides a green fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control).\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003ePathway dissection via targeted knockdown in vivo or in vitro\u003c\/li\u003e\n\u003cli\u003ePhenotype screening where reversible\/partial reduction is useful\u003c\/li\u003e\n\u003cli\u003eComplementary studies alongside overexpression or rescue constructs\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse multiple independent targeting sequences when feasible to reduce sequence-specific artifacts\u003c\/li\u003e\n\u003cli\u003eInclude a non-targeting control construct\u003c\/li\u003e\n\u003cli\u003eMeasure knockdown at the RNA\/protein level in the same tissue region used for phenotyping\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073438802285,"sku":"AAVX-7674-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073617781101,"sku":"AAVX-7674-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073617846637,"sku":"AAVX-7674-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073617912173,"sku":"AAVX-7674-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 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