{"product_id":"raav-cs-crm4-amhc-cre-wpre-hgh-polya-bhv12400230","title":"AAV-CS-CRM4-aMHC-Cre-WPRE-hGH-polyA","description":"\u003cstyle\u003e .bhp-aav{--ink:#0f2231;--ink-soft:#3d5566;--muted:#6b8190;--line:#e4ecf0;--paper:#fff;--mist:#f5f9fa;--vd:#3730a3;--vm:#6366f1;--vw:#eef2ff;--teal:#0e8a86;--teal-wash:#ecf7f6;--amber:#c77d1a;--amber-wash:#fbf3e6;--radius:14px;--shadow:0 1px 2px rgba(15,34,49,.04),0 8px 24px rgba(15,34,49,.05);font-family:inherit;color:var(--ink);line-height:1.62;max-width:1080px;margin:0 auto;padding:.5rem;-webkit-font-smoothing:antialiased} .bhp-aav *{box-sizing:border-box} @keyframes bhpUp{from{opacity:0;transform:translateY(14px)}to{opacity:1;transform:none}} .bhp-aav .bhp-card,.bhp-aav .bhp-hero{animation:bhpUp .6s cubic-bezier(.2,.7,.2,1) both} .bhp-aav .bhp-card:nth-of-type(2){animation-delay:.05s}.bhp-aav .bhp-card:nth-of-type(3){animation-delay:.1s}.bhp-aav .bhp-grid2{animation-delay:.12s} .bhp-aav .bhp-hero{position:relative;overflow:hidden;border-radius:18px;margin-bottom:1.5rem;padding:2.4rem 2.2rem;color:#fff;background:radial-gradient(120% 140% at 100% 0%,rgba(255,255,255,.10),transparent 55%),linear-gradient(135deg,var(--vd) 0%,var(--vm) 100%)} .bhp-aav .bhp-hero::after{content:\"\";position:absolute;inset:0;pointer-events:none;opacity:.5;background-image:linear-gradient(rgba(255,255,255,.07) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.07) 1px,transparent 1px);background-size:26px 26px;-webkit-mask-image:radial-gradient(80% 100% at 90% 0%,#000,transparent 70%);mask-image:radial-gradient(80% 100% at 90% 0%,#000,transparent 70%)} .bhp-aav .bhp-kicker{position:relative;display:inline-flex;align-items:center;gap:.5rem;font-size:.74rem;font-weight:700;letter-spacing:.14em;text-transform:uppercase;color:#fff;background:rgba(255,255,255,.16);border:1px solid rgba(255,255,255,.30);padding:.35rem .75rem;border-radius:999px;margin-bottom:1rem} .bhp-aav .bhp-kicker::before{content:\"\\25C9\";font-size:.7rem;line-height:1} .bhp-aav .bhp-htitle{position:relative;margin:.1rem 0 .35rem;font-size:2rem;font-weight:800;letter-spacing:-.01em;color:#fff;line-height:1.15;word-break:break-word} .bhp-aav .bhp-hsub{position:relative;margin:0;font-size:1.02rem;color:rgba(255,255,255,.92);max-width:64ch} .bhp-aav .bhp-chips{position:relative;display:flex;flex-wrap:wrap;gap:.5rem;margin-top:1.15rem} .bhp-aav .bhp-chip{font-size:.8rem;font-weight:600;color:var(--vd);background:rgba(255,255,255,.94);border-radius:999px;padding:.34rem .8rem;border:1px solid rgba(255,255,255,.6)} .bhp-aav .bhp-card{background:var(--paper);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow);padding:1.6rem 1.7rem;margin-bottom:1.1rem} .bhp-aav .bhp-head{display:flex;align-items:center;gap:.85rem;margin-bottom:.9rem} .bhp-aav .bhp-ico{flex:none;width:2.6rem;height:2.6rem;border-radius:10px;display:flex;align-items:center;justify-content:center;background:var(--vw);color:var(--vd);border:1px solid rgba(0,0,0,.06)} .bhp-aav .bhp-ico svg{width:1.35rem;height:1.35rem} .bhp-aav h2.bhp-h{margin:0;font-size:1.18rem;font-weight:800;letter-spacing:-.01em;color:var(--ink)} .bhp-aav .bhp-card p{margin:0 0 .6rem;color:var(--ink-soft);font-size:1.01rem}.bhp-aav .bhp-card p:last-child{margin-bottom:0} .bhp-aav .bhp-facts{display:grid;grid-template-columns:repeat(4,1fr);gap:.7rem;margin:1rem 0 .2rem} .bhp-aav .bhp-fact{background:var(--mist);border:1px solid var(--line);border-radius:11px;padding:.85rem .9rem} .bhp-aav .bhp-fact .k{font-size:.7rem;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:var(--muted);display:block;margin-bottom:.25rem} .bhp-aav .bhp-fact .v{font-size:1.0rem;font-weight:700;color:var(--ink);word-break:break-word} .bhp-aav .bhp-note{margin-top:1rem;padding:.85rem 1rem;border-left:3px solid var(--vm);background:var(--vw);border-radius:0 10px 10px 0;font-size:.96rem;color:var(--ink-soft);font-style:italic} .bhp-aav .bhp-grid2{display:grid;grid-template-columns:1fr 1fr;gap:1.1rem;margin-bottom:1.1rem} .bhp-aav .bhp-grid2 .bhp-card{margin-bottom:0;height:100%} .bhp-aav ul.bhp-list{list-style:none;margin:.3rem 0 0;padding:0} .bhp-aav ul.bhp-list li{position:relative;padding:.55rem 0 .55rem 1.9rem;color:var(--ink-soft);font-size:1rem;border-bottom:1px solid var(--mist)} .bhp-aav ul.bhp-list li:last-child{border-bottom:none} .bhp-aav ul.bhp-check li::before{content:\"\\2713\";position:absolute;left:.15rem;top:.55rem;color:var(--teal);font-weight:800} .bhp-aav ul.bhp-step li::before{content:\"\\25B8\";position:absolute;left:.3rem;top:.55rem;color:var(--amber);font-weight:800} .bhp-aav .bhp-head.amber .bhp-ico{background:var(--amber-wash);color:var(--amber);border-color:#f0dcbf} .bhp-aav .bhp-valid{border:1px solid #cfe9e7;background:linear-gradient(180deg,var(--teal-wash),#fff);border-left:5px solid var(--teal)} .bhp-aav .bhp-valid .bhp-ico{background:var(--teal-wash);color:#0b6e6b;border-color:#cfe9e7} @media(max-width:880px){.bhp-aav .bhp-facts{grid-template-columns:repeat(2,1fr)}.bhp-aav .bhp-grid2{grid-template-columns:1fr}.bhp-aav .bhp-htitle{font-size:1.6rem}} @media(max-width:480px){.bhp-aav .bhp-facts{grid-template-columns:1fr}.bhp-aav .bhp-card{padding:1.3rem 1.25rem}} \u003c\/style\u003e\u003cdiv class=\"bhp-aav\"\u003e \u003cheader class=\"bhp-hero\"\u003e\u003cspan class=\"bhp-kicker\"\u003eRecombinase \/ driver · Research Use Only\u003c\/span\u003e\u003ch2 class=\"bhp-htitle\"\u003eCre\u003c\/h2\u003e\n\u003cp class=\"bhp-hsub\"\u003eConstitutive expression of Cre driven by the CS-CRM4-aMHC promoter.\u003c\/p\u003e\n\u003cdiv class=\"bhp-chips\"\u003e\n\u003cspan class=\"bhp-chip\"\u003eCS-CRM4-aMHC promoter\u003c\/span\u003e\u003cspan class=\"bhp-chip\"\u003eConstitutive\u003c\/span\u003e\u003cspan class=\"bhp-chip\"\u003eTranscriptional regulator \/ recombinase\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/header\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M9 3v4M15 3v4M9 7c0 4-3 5-3 9a6 6 0 0 0 12 0c0-4-3-5-3-9\"\u003e\u003c\/path\u003e\u003cpath d=\"M8 14h8\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eResearch background\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eThis AAV provides recombinase-based genetic access, enabling conditional control of downstream payloads in genetically defined cells. Recombinase tools are widely used to restrict expression, create intersectional logic, or enable lineage\/cell-type targeting.\u003c\/p\u003e\u003c\/section\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"3\"\u003e\u003c\/circle\u003e\u003cpath d=\"M12 2v3M12 19v3M2 12h3M19 12h3M5 5l2 2M17 17l2 2M19 5l-2 2M7 17l-2 2\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eMechanism and expected readouts\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eRecombinase expression catalyzes site-specific DNA recombination at matching target sites, permanently switching genetic states in infected cells. This can gate expression of FLEX\/DIO payloads or enable intersectional strategies when combined with other recombinases.\u003c\/p\u003e\u003c\/section\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M4 7h16M4 12h10M4 17h7\"\u003e\u003c\/path\u003e\u003ccircle cx=\"18\" cy=\"15\" r=\"3\"\u003e\u003c\/circle\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eExpression design and interpretation\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eExpression is driven by the CS-CRM4-aMHC promoter, which determines where and how strongly the payload is expressed in your system (αMHC cardiac promoter enhanced by the synthetic CS-CRM4 regulatory module, giving cardiomyocyte-restricted expression). The construct's regulatory logic controls where\/when the payload is active; expression is constitutive (no recombinase or inducer required). The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control). CS-CRM4 is a synthetic cardiac enhancer ligated upstream of the αMHC promoter to raise transcription while preserving cardiomyocyte specificity, supporting high, stable expression in the heart.\u003c\/p\u003e\n\u003cdiv class=\"bhp-facts\"\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003ePromoter\u003c\/span\u003e\u003cspan class=\"v\"\u003eCS-CRM4-aMHC\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eExpression control\u003c\/span\u003e\u003cspan class=\"v\"\u003eConstitutive\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eReporter \/ tag\u003c\/span\u003e\u003cspan class=\"v\"\u003eNone\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eLocalization\u003c\/span\u003e\u003cspan class=\"v\"\u003eConfirm by imaging\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"bhp-note\"\u003eSubcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e\u003c\/section\u003e \u003cdiv class=\"bhp-grid2\"\u003e\n\u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M20 6 9 17l-5-5\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eCommon research applications\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cul class=\"bhp-list bhp-check\"\u003e\n\u003cli\u003eConditional targeting for cell-type or projection-specific experiments\u003c\/li\u003e\n\u003cli\u003eIntersectional labeling or manipulation strategies\u003c\/li\u003e\n\u003cli\u003ePermanent genetic switching for lineage or fate-mapping workflows\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/section\u003e\u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M12 9v4M12 17h.01\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.3 3.9 1.8 18a2 2 0 0 0 1.7 3h17a2 2 0 0 0 1.7-3L13.7 3.9a2 2 0 0 0-3.4 0Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eExperimental considerations\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cul class=\"bhp-list bhp-step\"\u003e\n\u003cli\u003eVerify recombination efficiency with a compatible reporter in your system\u003c\/li\u003e\n\u003cli\u003eAccount for irreversible switching when designing longitudinal studies\u003c\/li\u003e\n\u003cli\u003eUse appropriate negative controls (no recombinase or mismatched recombinase lines)\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/section\u003e\n\u003c\/div\u003e \u003csection class=\"bhp-card bhp-valid\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M12 3l7 3v5c0 4.5-3 8-7 10-4-2-7-5.5-7-10V6l7-3Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eControls and validation\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e\u003c\/section\u003e \u003c\/div\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073466589549,"sku":"AAVX-0577-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180224877,"sku":"AAVX-0577-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180290413,"sku":"AAVX-0577-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180355949,"sku":"AAVX-0577-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180421485,"sku":"AAVX-0577-26-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6m \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180487021,"sku":"AAVX-0577-26m-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6.2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180552557,"sku":"AAVX-0577-26p2-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180618093,"sku":"AAVX-0577-28-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180683629,"sku":"AAVX-0577-29-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"rAAV2-retro \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180749165,"sku":"AAVX-0577-2retro-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.eB \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180814701,"sku":"AAVX-0577-2PHPpeB-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-B10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180880237,"sku":"AAVX-0577-2B10-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.S \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075180945773,"sku":"AAVX-0577-2PHPpS-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PAN \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181011309,"sku":"AAVX-0577-2PAN-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-DJ \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181076845,"sku":"AAVX-0577-2DJ-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-7m8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181142381,"sku":"AAVX-0577-27m8-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-ShH10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181207917,"sku":"AAVX-0577-2ShH10-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Rh10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181273453,"sku":"AAVX-0577-2Rh10-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Anc80L65 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181338989,"sku":"AAVX-0577-2Anc80L65-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BR1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181404525,"sku":"AAVX-0577-2BR1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BI30 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181470061,"sku":"AAVX-0577-2BI30-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-SCH9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181535597,"sku":"AAVX-0577-2SCH9-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181601133,"sku":"AAVX-0577-MaCPNS1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181666669,"sku":"AAVX-0577-MaCPNS2-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"mac \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181732205,"sku":"AAVX-0577-mac-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/11 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181797741,"sku":"AAVX-0577-211-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"MyoAAV 2A \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181863277,"sku":"AAVX-0577-MyoAAV2A-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"VCAP-102 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53075181928813,"sku":"AAVX-0577-VCAP102-12","price":472.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BHV12400230_raav-cs-crm4-alphamhc-cre-wpre-hgh-polya_PT-0577.png?v=1772647851","url":"https:\/\/www.ebiohippo.com\/products\/raav-cs-crm4-amhc-cre-wpre-hgh-polya-bhv12400230","provider":"BioHippo","version":"1.0","type":"link"}