{"product_id":"raav-ef1a-egfp-5-mir-30-shrna-scramble-3-mir-30-wpres-bhv12401164","title":"AAV-EF1α-EGFP-5'miR-30-shRNA(scramble)-3'miR-30-WPREs","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports gene silencing approaches (e.g., RNAi-based knockdown) for functional studies where partial reduction is sufficient or preferred. Silencing constructs can be advantageous when complete knockout is lethal or causes compensatory effects.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eKnockdown efficiency depends on target sequence choice, expression level, and cell-type context. Validation typically combines mRNA\/protein measurements with functional readouts.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by the EF1α promoter, which determines where and how strongly the payload is expressed in your system. The expression design includes regulatory elements that can constrain activity to specific genetic contexts or experimental conditions. A built-in reporter\/tag supports validation and localization; GFP\/EGFP provides a green fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control).\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003ePathway dissection via targeted knockdown in vivo or in vitro\u003c\/li\u003e\n\u003cli\u003ePhenotype screening where reversible\/partial reduction is useful\u003c\/li\u003e\n\u003cli\u003eComplementary studies alongside overexpression or rescue constructs\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse multiple independent targeting sequences when feasible to reduce sequence-specific artifacts\u003c\/li\u003e\n\u003cli\u003eInclude a non-targeting control construct\u003c\/li\u003e\n\u003cli\u003eMeasure knockdown at the RNA\/protein level in the same tissue region used for phenotyping\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073438703981,"sku":"AAVX-4923-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073764122989,"sku":"AAVX-4923-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073764188525,"sku":"AAVX-4923-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073764254061,"sku":"AAVX-4923-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 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