{"product_id":"raav-gfap-egfp-5-mir-30a-shrna-scramble-3-mir30a-wpres-bhv12401207","title":"AAV-GFAP-EGFP-5'miR-30a-shRNA(scramble)-3'-miR30a-WPREs","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports gene silencing approaches (e.g., RNAi-based knockdown) for functional studies where partial reduction is sufficient or preferred. Silencing constructs can be advantageous when complete knockout is lethal or causes compensatory effects.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eKnockdown efficiency depends on target sequence choice, expression level, and cell-type context. Validation typically combines mRNA\/protein measurements with functional readouts.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by a promoter choice that shapes cell-type bias and expression strength; GFAP promoter, commonly used for astrocyte-enriched expression. The expression design includes regulatory elements that can constrain activity to specific genetic contexts or experimental conditions. A built-in reporter\/tag supports validation and localization; GFP\/EGFP provides a green fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control).\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003ePathway dissection via targeted knockdown in vivo or in vitro\u003c\/li\u003e\n\u003cli\u003ePhenotype screening where reversible\/partial reduction is useful\u003c\/li\u003e\n\u003cli\u003eComplementary studies alongside overexpression or rescue constructs\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse multiple independent targeting sequences when feasible to reduce sequence-specific artifacts\u003c\/li\u003e\n\u003cli\u003eInclude a non-targeting control construct\u003c\/li\u003e\n\u003cli\u003eMeasure knockdown at the RNA\/protein level in the same tissue region used for phenotyping\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073439392109,"sku":"AAVX-1330-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686528365,"sku":"AAVX-1330-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686593901,"sku":"AAVX-1330-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686659437,"sku":"AAVX-1330-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686724973,"sku":"AAVX-1330-26-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6m \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686790509,"sku":"AAVX-1330-26m-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6.2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686856045,"sku":"AAVX-1330-26p2-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686921581,"sku":"AAVX-1330-28-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073686987117,"sku":"AAVX-1330-29-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"rAAV2-retro \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687052653,"sku":"AAVX-1330-2retro-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.eB \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687118189,"sku":"AAVX-1330-2PHPpeB-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-B10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687183725,"sku":"AAVX-1330-2B10-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.S \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687249261,"sku":"AAVX-1330-2PHPpS-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PAN \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687314797,"sku":"AAVX-1330-2PAN-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-DJ \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687380333,"sku":"AAVX-1330-2DJ-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-7m8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687445869,"sku":"AAVX-1330-27m8-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-ShH10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687511405,"sku":"AAVX-1330-2ShH10-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Rh10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687576941,"sku":"AAVX-1330-2Rh10-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Anc80L65 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687642477,"sku":"AAVX-1330-2Anc80L65-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BR1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687708013,"sku":"AAVX-1330-2BR1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BI30 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687773549,"sku":"AAVX-1330-2BI30-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-SCH9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687839085,"sku":"AAVX-1330-2SCH9-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687904621,"sku":"AAVX-1330-MaCPNS1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073687970157,"sku":"AAVX-1330-MaCPNS2-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"mac \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073688035693,"sku":"AAVX-1330-mac-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/11 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073688101229,"sku":"AAVX-1330-211-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"MyoAAV 2A \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073688166765,"sku":"AAVX-1330-MyoAAV2A-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"VCAP-102 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073688232301,"sku":"AAVX-1330-VCAP102-12","price":472.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BHV12401207_raav-gfap-egfp-5-mir-30a-shrna-scramble-3-mir30a-wpres_PT-1330.jpg?v=1772647695","url":"https:\/\/www.ebiohippo.com\/products\/raav-gfap-egfp-5-mir-30a-shrna-scramble-3-mir30a-wpres-bhv12401207","provider":"BioHippo","version":"1.0","type":"link"}