{"product_id":"raav-mdlx-dio-hm4d-gi-mcherry-wpre-hgh-polya-bhv12400412","title":"AAV-mDLX-DIO-hM4D(Gi)-mCherry-WPRE-hGH-polyA","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports chemogenetic modulation of cellular signaling or excitability via engineered receptors. Chemogenetics is commonly used when longer-duration, less temporally precise modulation is desired compared with optogenetics.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eExpression of the engineered receptor enables ligand-dependent control over downstream signaling. Typical considerations include ligand selection\/dose, onset and washout kinetics, and potential off-target effects at high doses.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by the mDLX promoter, which determines where and how strongly the payload is expressed in your system. The construct includes regulatory logic that controls where\/when the payload is active; Cre-dependent control restricts expression to cells expressing Cre recombinase. A built-in reporter\/tag supports validation and localization; mCherry provides a red fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control). Chemogenetic receptors enable ligand-dependent modulation with minutes-to-hours time scales, often suitable for behavioral paradigms.\u003c\/p\u003e \u003cp\u003eSubcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eSustained activation or inhibition of defined cell populations\u003c\/li\u003e\n\u003cli\u003eLonger-timescale behavioral modulation (minutes to hours)\u003c\/li\u003e\n\u003cli\u003eDissection of neuromodulatory pathways via receptor-specific signaling\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse vehicle controls and dose-response designs when possible\u003c\/li\u003e\n\u003cli\u003eAllow adequate time for ligand onset and washout in your behavioral schedule\u003c\/li\u003e\n\u003cli\u003eValidate expression\/function in a subset of animals or cultures before scaling up\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073439818093,"sku":"AAVX-1191-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661198701,"sku":"AAVX-1191-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661264237,"sku":"AAVX-1191-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661329773,"sku":"AAVX-1191-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661395309,"sku":"AAVX-1191-26-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6m \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661460845,"sku":"AAVX-1191-26m-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6.2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661526381,"sku":"AAVX-1191-26p2-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661591917,"sku":"AAVX-1191-28-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661657453,"sku":"AAVX-1191-29-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"rAAV2-retro \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661722989,"sku":"AAVX-1191-2retro-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.eB \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661788525,"sku":"AAVX-1191-2PHPpeB-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-B10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661854061,"sku":"AAVX-1191-2B10-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.S \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661919597,"sku":"AAVX-1191-2PHPpS-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PAN \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073661985133,"sku":"AAVX-1191-2PAN-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-DJ \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662050669,"sku":"AAVX-1191-2DJ-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-7m8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662116205,"sku":"AAVX-1191-27m8-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-ShH10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662181741,"sku":"AAVX-1191-2ShH10-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Rh10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662247277,"sku":"AAVX-1191-2Rh10-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Anc80L65 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662312813,"sku":"AAVX-1191-2Anc80L65-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BR1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662378349,"sku":"AAVX-1191-2BR1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BI30 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662443885,"sku":"AAVX-1191-2BI30-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-SCH9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662509421,"sku":"AAVX-1191-2SCH9-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662574957,"sku":"AAVX-1191-MaCPNS1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662640493,"sku":"AAVX-1191-MaCPNS2-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"mac \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662706029,"sku":"AAVX-1191-mac-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/11 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662771565,"sku":"AAVX-1191-211-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"MyoAAV 2A \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662837101,"sku":"AAVX-1191-MyoAAV2A-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"VCAP-102 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073662902637,"sku":"AAVX-1191-VCAP102-12","price":472.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BHV12400412_raav-mdlx-dio-hm4d-gi-mcherry-wpre-hgh-polya_PT-1191.png?v=1772647695","url":"https:\/\/www.ebiohippo.com\/products\/raav-mdlx-dio-hm4d-gi-mcherry-wpre-hgh-polya-bhv12400412","provider":"BioHippo","version":"1.0","type":"link"}