{"product_id":"raav-th-dio-hm3d-gq-egfp-wpres-bhv12401553","title":"AAV-TH-DIO-hM3D(Gq)-EGFP-WPREs","description":"\u003cstyle\u003e\n.aav-detail{font-family:-apple-system,BlinkMacSystemFont,'Segoe UI',Roboto,sans-serif;color:#1e293b;max-width:1100px;margin:0 auto;padding:2rem;font-size:1.5rem}\n.aav-hero{text-align:center;padding:3rem 2rem;border-radius:16px;margin-bottom:3rem;border:2px solid #ddd6fe}\n.aav-badge{display:inline-block;color:white;padding:.5rem 1.5rem;border-radius:30px;font-size:1.25rem;font-weight:700;margin-bottom:1rem;text-transform:uppercase;letter-spacing:.5px;background:#7c3aed}\n.aav-title{font-size:3rem;font-weight:800;color:#0f172a;margin:0 0 1rem 0}\n.aav-subtitle{font-size:1.75rem;color:#64748b;margin:0 0 1.5rem 0;font-weight:500}\n.aav-tags{display:flex;justify-content:center;gap:1rem;flex-wrap:wrap}\n.aav-tag{background:white;padding:.5rem 1.25rem;border-radius:20px;font-size:1.25rem;font-weight:600;border:2px solid #7c3aed80;color:#7c3aed}\n.aav-section{background:white;border-radius:16px;padding:2.5rem;margin-bottom:2rem;border:2px solid #e2e8f0}\n.aav-section.hl-teal{background:#f0fdfa;border-left:6px solid #14b8a6;border-color:#14b8a6}\n.aav-hdr{display:flex;align-items:center;gap:1.25rem;margin-bottom:1.5rem;padding-bottom:1.25rem;border-bottom:2px solid #f1f5f9}\n.aav-icon{width:4rem;height:4rem;border-radius:12px;display:flex;align-items:center;justify-content:center;flex-shrink:0}\n.aav-icon svg{width:2.25rem;height:2.25rem;color:white}\n.aav-section h3{font-size:2rem;font-weight:800;color:#0f172a;margin:0}\n.aav-text{font-size:1.5rem;line-height:1.6;color:#334155;margin:0}\n.aav-text.note{margin-top:1.5rem;padding-top:1.5rem;border-top:2px solid #f1f5f9;font-style:italic;color:#475569}\n.design-grid{display:grid;grid-template-columns:1fr 1fr;gap:1.5rem;margin-bottom:1rem}\n.design-item{background:#f8fafc;padding:1.5rem;border-radius:12px;border:2px solid #e2e8f0}\n.design-item.span2{background:#f5f3ff;border-color:#c4b5fd;grid-column:1\/-1}\n.design-item h4{font-size:1.5rem;font-weight:700;color:#0f172a;margin:0 0 .75rem 0}\n.design-item p{font-size:1.375rem;line-height:1.5;color:#475569;margin:0}\n.aav-two-col{display:grid;grid-template-columns:1fr 1fr;gap:2rem;margin-bottom:2rem}\n.aav-two-col .aav-section{margin-bottom:0;height:100%}\n.aav-list{list-style:none;padding:0;margin:0}\n.aav-list li{padding:1rem 0 1rem 3rem;position:relative;font-size:1.5rem;line-height:1.5;color:#334155;border-bottom:2px solid #f8fafc}\n.aav-list li:last-child{border-bottom:none}\n.aav-list.check li::before{content:\"✓\";position:absolute;left:0;color:#10b981;font-weight:800;font-size:2rem;top:.875rem}\n.aav-list.bullet li::before{content:\"•\";position:absolute;left:.5rem;color:#f59e0b;font-weight:900;font-size:2.5rem;line-height:1;top:.5rem}\n@media(max-width:1024px){.design-grid,.aav-two-col{grid-template-columns:1fr}}\n@media(max-width:768px){.aav-detail{padding:1.5rem}.aav-title{font-size:2.25rem}.aav-section h3{font-size:1.75rem}.aav-text,.aav-list li{font-size:1.375rem}}\n\u003c\/style\u003e\n\u003cdiv class=\"aav-detail\"\u003e\n\u003cdiv style=\"background: linear-gradient(135deg,#f5f3ff 0%,#ede9fe 100%); border-color: #ddd6fe;\" class=\"aav-hero\"\u003e\n\u003cdiv style=\"background: #7c3aed;\" class=\"aav-badge\"\u003eChemogenetic\u003c\/div\u003e\n\u003ch2 class=\"aav-title\"\u003ehM3D(Gq)\u003c\/h2\u003e\n\u003cp class=\"aav-subtitle\"\u003eCre-dependent • TH Promoter • EGFP Reporter\u003c\/p\u003e\n\u003cdiv class=\"aav-tags\"\u003e\n\u003cspan class=\"aav-tag\"\u003eBHV12401553\u003c\/span\u003e\u003cspan class=\"aav-tag\"\u003eCre-dependent, Excitatory\u003c\/span\u003e\u003cspan class=\"aav-tag\"\u003eMembrane-Targeted\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003csection class=\"aav-section\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #6366f1;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M12 2a10 10 0 1 0 10 10H12V2z\"\u003e\u003c\/path\u003e\u003cpath d=\"M12 2a10 10 0 0 1 10 10\"\u003e\u003c\/path\u003e\u003cpath d=\"M12 12L2.5 8.5\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eResearch Background\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"aav-text\"\u003eThis AAV supports chemogenetic modulation of cellular signaling or excitability via engineered receptors. Chemogenetics is commonly used when longer-duration, less temporally precise modulation is desired compared with optogenetics.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"aav-section\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #3b82f6;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003ccircle r=\"3\" cy=\"12\" cx=\"12\"\u003e\u003c\/circle\u003e\u003cpath d=\"M12 2v4m0 12v4m10-10h-4M6 12H2m15.364-6.364l-2.828 2.828m-8.486 8.486l-2.828 2.828m14.142 0l-2.828-2.828M6.343 6.343L3.515 3.515\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eMechanism and Expected Readouts\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"aav-text\"\u003eExpression of the engineered receptor enables ligand-dependent control over downstream signaling. Typical considerations include ligand selection and dose, onset and washout kinetics, and potential off-target effects at high doses.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"aav-section\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #8b5cf6;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M10 20l4-16m4 4l4 4-4 4M6 16l-4-4 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eExpression Design and Interpretation\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"design-grid\"\u003e\n\u003cdiv class=\"design-item\"\u003e\n\u003ch4\u003ePromoter\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eTH\u003c\/strong\u003e — Catecholaminergic neuron-enriched; associated with dopaminergic and noradrenergic cells\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"design-item\"\u003e\n\u003ch4\u003eExpression Control\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eCre-dependent\u003c\/strong\u003e — Cre-dependent (DIO\/FLEX) — expression restricted to cells co-expressing Cre recombinase\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"design-item\"\u003e\n\u003ch4\u003eReporter \/ Tag\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eEGFP\u003c\/strong\u003e — EGFP (green fluorescent protein (Ex ~488 nm \/ Em ~507 nm)) — use for expression verification, morphology, and targeting validation\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"design-item\"\u003e\n\u003ch4\u003eSubcellular Localization\u003c\/h4\u003e\n\u003cp\u003ePlasma membrane — membrane-anchored; confirm surface expression by imaging\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"design-item span2\"\u003e\n\u003ch4\u003ePrimary Payload\u003c\/h4\u003e\n\u003cp\u003ehM3D(Gq) — function class: Cre-dependent, Excitatory; chemogenetic receptor enabling ligand-dependent modulation with minutes-to-hours time scales\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"aav-text note\"\u003eThis product (BHV12401553) contains hM3D(Gq) as its primary payload. Subcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003cdiv class=\"aav-two-col\"\u003e\n\u003csection class=\"aav-section\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #10b981;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M9 12l2 2 4-4m6 2a9 9 0 11-18 0 9 9 0 0118 0z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eCommon Research Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cul class=\"aav-list check\"\u003e\n\u003cli\u003eSustained activation or inhibition of defined cell populations\u003c\/li\u003e\n\u003cli\u003eLonger-timescale behavioral modulation (minutes to hours)\u003c\/li\u003e\n\u003cli\u003eDissection of neuromodulatory pathways via receptor-specific signaling\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003csection class=\"aav-section\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #f59e0b;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M12 9v2m0 4h.01m-6.938 4h13.856c1.54 0 2.502-1.667 1.732-3L13.732 4c-.77-1.333-2.694-1.333-3.464 0L3.34 16c-.77 1.333.192 3 1.732 3z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eExperimental Considerations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cul class=\"aav-list bullet\"\u003e\n\u003cli\u003eUse vehicle controls and dose-response designs when possible\u003c\/li\u003e\n\u003cli\u003eAllow adequate time for ligand onset and washout in your behavioral schedule\u003c\/li\u003e\n\u003cli\u003eValidate expression and function in a subset of animals or cultures before scaling up\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003csection class=\"aav-section hl-teal\"\u003e\n\u003cdiv class=\"aav-hdr\"\u003e\n\u003cdiv style=\"background: #14b8a6;\" class=\"aav-icon\"\u003e\u003csvg stroke-width=\"2\" stroke=\"currentColor\" fill=\"none\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M9 12l2 2 4-4m5.618-4.016A11.955 11.955 0 0112 2.944a11.955 11.955 0 01-8.618 3.04A12.02 12.02 0 003 9c0 5.591 3.824 10.29 9 11.622 5.176-1.332 9-6.03 9-11.622 0-1.042-.133-2.052-.382-3.016z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3\u003eControls and Validation\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"aav-text\"\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073436049773,"sku":"AAVX-6885-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073511252333,"sku":"AAVX-6885-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073511317869,"sku":"AAVX-6885-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073511383405,"sku":"AAVX-6885-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073511448941,"sku":"AAVX-6885-26-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6m \/ \u003e=2.00E+12 vg\/mL \/ 100 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