{"product_id":"raav-th-dio-hm4d-gi-mcherry-wpres-bhv12401599","title":"AAV-TH-DIO-hM4D(Gi)-mCherry-WPREs","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports chemogenetic modulation of cellular signaling or excitability via engineered receptors. Chemogenetics is commonly used when longer-duration, less temporally precise modulation is desired compared with optogenetics.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eExpression of the engineered receptor enables ligand-dependent control over downstream signaling. Typical considerations include ligand selection\/dose, onset and washout kinetics, and potential off-target effects at high doses.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by a promoter choice that shapes cell-type bias and expression strength; TH promoter, associated with catecholaminergic neuron targeting (e.g., dopaminergic\/noradrenergic). The construct includes regulatory logic that controls where\/when the payload is active; Cre-dependent control restricts expression to cells expressing Cre recombinase. A built-in reporter\/tag supports validation and localization; mCherry provides a red fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control). Chemogenetic receptors enable ligand-dependent modulation with minutes-to-hours time scales, often suitable for behavioral paradigms.\u003c\/p\u003e \u003cp\u003eSubcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eSustained activation or inhibition of defined cell populations\u003c\/li\u003e\n\u003cli\u003eLonger-timescale behavioral modulation (minutes to hours)\u003c\/li\u003e\n\u003cli\u003eDissection of neuromodulatory pathways via receptor-specific signaling\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse vehicle controls and dose-response designs when possible\u003c\/li\u003e\n\u003cli\u003eAllow adequate time for ligand onset and washout in your behavioral schedule\u003c\/li\u003e\n\u003cli\u003eValidate expression\/function in a subset of animals or cultures before scaling up\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073440506221,"sku":"AAVX-6000-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073652187501,"sku":"AAVX-6000-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073652253037,"sku":"AAVX-6000-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 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