{"product_id":"raav-tre-tight-hm4d-gi-mcherry-wpre-hgh-polya-bhv12400076","title":"AAV-TRE-tight-hM4D(Gi)-mCherry-WPRE-hGH polyA","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports chemogenetic modulation of cellular signaling or excitability via engineered receptors. Chemogenetics is commonly used when longer-duration, less temporally precise modulation is desired compared with optogenetics.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eExpression of the engineered receptor enables ligand-dependent control over downstream signaling. Typical considerations include ligand selection\/dose, onset and washout kinetics, and potential off-target effects at high doses.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by the TRE-tight promoter, which determines where and how strongly the payload is expressed in your system (Tet-responsive cells). The construct's regulatory logic controls where\/when the payload is active; Tet-regulated control requires a tTA\/rtTA driver and doxycycline to gate expression. A built-in reporter\/tag supports validation and localization; mCherry provides a red fluorescent protein (Ex ~587 nm \/ Em ~610 nm) readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control). Chemogenetic receptors enable ligand-dependent modulation with minutes-to-hours time scales, often suitable for behavioral paradigms.\u003c\/p\u003e \u003cp\u003eSubcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eSustained activation or inhibition of defined cell populations\u003c\/li\u003e \u003cli\u003eLonger-timescale behavioral modulation (minutes to hours)\u003c\/li\u003e \u003cli\u003eDissection of neuromodulatory pathways via receptor-specific signaling\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse vehicle controls and dose-response designs when possible\u003c\/li\u003e \u003cli\u003eAllow adequate time for ligand onset and washout in your behavioral schedule\u003c\/li\u003e \u003cli\u003eValidate expression\/function in a subset 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