{"product_id":"raav-u6-shrna-scramble-u6-shrna-scramble-cmv-mcherry-sv40-polya-bhv12401158","title":"AAV-U6-shRNA(scramble)-U6-shRNA(scramble)-CMV-mCherry-SV40-polyA","description":"\u003ch2\u003eResearch background\u003c\/h2\u003e \u003cp\u003eThis AAV supports gene silencing approaches (e.g., RNAi-based knockdown) for functional studies where partial reduction is sufficient or preferred. Silencing constructs can be advantageous when complete knockout is lethal or causes compensatory effects.\u003c\/p\u003e \u003ch2\u003eMechanism and expected readouts\u003c\/h2\u003e \u003cp\u003eKnockdown efficiency depends on target sequence choice, expression level, and cell-type context. Validation typically combines mRNA\/protein measurements with functional readouts.\u003c\/p\u003e \u003ch2\u003eExpression design and interpretation\u003c\/h2\u003e \u003cp\u003eExpression is driven by the CMV + U6 (dual) promoter, which determines where and how strongly the payload is expressed in your system. The expression design includes regulatory elements that can constrain activity to specific genetic contexts or experimental conditions. A built-in reporter\/tag supports validation and localization; mCherry provides a red fluorescent readout for expression, morphology, and targeting validation. The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control).\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003ePathway dissection via targeted knockdown in vivo or in vitro\u003c\/li\u003e\n\u003cli\u003ePhenotype screening where reversible\/partial reduction is useful\u003c\/li\u003e\n\u003cli\u003eComplementary studies alongside overexpression or rescue constructs\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eExperimental considerations\u003c\/h2\u003e \u003cul\u003e\n\u003cli\u003eUse multiple independent targeting sequences when feasible to reduce sequence-specific artifacts\u003c\/li\u003e\n\u003cli\u003eInclude a non-targeting control construct\u003c\/li\u003e\n\u003cli\u003eMeasure knockdown at the RNA\/protein level in the same tissue region used for phenotyping\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch2\u003eControls and validation\u003c\/h2\u003e \u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53073458299245,"sku":"AAVX-2740-21-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074775900525,"sku":"AAVX-2740-22-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV1\/2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074775966061,"sku":"AAVX-2740-12-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/5 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776031597,"sku":"AAVX-2740-25-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776097133,"sku":"AAVX-2740-26-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6m \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776162669,"sku":"AAVX-2740-26m-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/6.2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776228205,"sku":"AAVX-2740-26p2-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776293741,"sku":"AAVX-2740-28-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776359277,"sku":"AAVX-2740-29-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"rAAV2-retro \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776424813,"sku":"AAVX-2740-2retro-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.eB \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776490349,"sku":"AAVX-2740-2PHPpeB-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-B10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776555885,"sku":"AAVX-2740-2B10-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PHP.S \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776621421,"sku":"AAVX-2740-2PHPpS-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-PAN \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776686957,"sku":"AAVX-2740-2PAN-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-DJ \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776752493,"sku":"AAVX-2740-2DJ-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-7m8 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776818029,"sku":"AAVX-2740-27m8-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-ShH10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776883565,"sku":"AAVX-2740-2ShH10-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Rh10 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074776949101,"sku":"AAVX-2740-2Rh10-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-Anc80L65 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777014637,"sku":"AAVX-2740-2Anc80L65-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BR1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777080173,"sku":"AAVX-2740-2BR1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-BI30 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777145709,"sku":"AAVX-2740-2BI30-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2-SCH9 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777211245,"sku":"AAVX-2740-2SCH9-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS1 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777276781,"sku":"AAVX-2740-MaCPNS1-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"MaCPNS2 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777342317,"sku":"AAVX-2740-MaCPNS2-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"mac \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777407853,"sku":"AAVX-2740-mac-12","price":472.0,"currency_code":"USD","in_stock":true},{"title":"AAV2\/11 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777473389,"sku":"AAVX-2740-211-12","price":397.0,"currency_code":"USD","in_stock":true},{"title":"MyoAAV 2A \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777538925,"sku":"AAVX-2740-MyoAAV2A-12","price":490.0,"currency_code":"USD","in_stock":true},{"title":"VCAP-102 \/ \u003e=2.00E+12 vg\/mL \/ 100 uL","offer_id":53074777604461,"sku":"AAVX-2740-VCAP102-12","price":472.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BHV12401158_raav-u6-shrna-scramble-u6-shrna-scramble-cmv-mcherry-sv40-polya_PT-2740.jpg?v=1772647828","url":"https:\/\/www.ebiohippo.com\/products\/raav-u6-shrna-scramble-u6-shrna-scramble-cmv-mcherry-sv40-polya-bhv12401158","provider":"BioHippo","version":"1.0","type":"link"}