{"product_id":"raav-u6-spsgrna-scramble-nestin-cre-wpres-bhv12401224","title":"AAV-U6-SpsgRNA(scramble)-Nestin-Cre-WPREs","description":"\u003cstyle\u003e .bhp-aav{--ink:#0f2231;--ink-soft:#3d5566;--muted:#6b8190;--line:#e4ecf0;--paper:#fff;--mist:#f5f9fa;--vd:#3730a3;--vm:#6366f1;--vw:#eef2ff;--teal:#0e8a86;--teal-wash:#ecf7f6;--amber:#c77d1a;--amber-wash:#fbf3e6;--radius:14px;--shadow:0 1px 2px rgba(15,34,49,.04),0 8px 24px rgba(15,34,49,.05);font-family:inherit;color:var(--ink);line-height:1.62;max-width:1080px;margin:0 auto;padding:.5rem;-webkit-font-smoothing:antialiased} .bhp-aav *{box-sizing:border-box} @keyframes bhpUp{from{opacity:0;transform:translateY(14px)}to{opacity:1;transform:none}} .bhp-aav .bhp-card,.bhp-aav .bhp-hero{animation:bhpUp .6s cubic-bezier(.2,.7,.2,1) both} .bhp-aav .bhp-card:nth-of-type(2){animation-delay:.05s}.bhp-aav .bhp-card:nth-of-type(3){animation-delay:.1s}.bhp-aav .bhp-grid2{animation-delay:.12s} .bhp-aav 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.bhp-kicker::before{content:\"\\25C9\";font-size:.7rem;line-height:1} .bhp-aav .bhp-htitle{position:relative;margin:.1rem 0 .35rem;font-size:2rem;font-weight:800;letter-spacing:-.01em;color:#fff;line-height:1.15;word-break:break-word} .bhp-aav .bhp-hsub{position:relative;margin:0;font-size:1.02rem;color:rgba(255,255,255,.92);max-width:64ch} .bhp-aav .bhp-chips{position:relative;display:flex;flex-wrap:wrap;gap:.5rem;margin-top:1.15rem} .bhp-aav .bhp-chip{font-size:.8rem;font-weight:600;color:var(--vd);background:rgba(255,255,255,.94);border-radius:999px;padding:.34rem .8rem;border:1px solid rgba(255,255,255,.6)} .bhp-aav .bhp-card{background:var(--paper);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow);padding:1.6rem 1.7rem;margin-bottom:1.1rem} .bhp-aav .bhp-head{display:flex;align-items:center;gap:.85rem;margin-bottom:.9rem} .bhp-aav .bhp-ico{flex:none;width:2.6rem;height:2.6rem;border-radius:10px;display:flex;align-items:center;justify-content:center;background:var(--vw);color:var(--vd);border:1px solid rgba(0,0,0,.06)} .bhp-aav .bhp-ico svg{width:1.35rem;height:1.35rem} .bhp-aav h2.bhp-h{margin:0;font-size:1.18rem;font-weight:800;letter-spacing:-.01em;color:var(--ink)} .bhp-aav .bhp-card p{margin:0 0 .6rem;color:var(--ink-soft);font-size:1.01rem}.bhp-aav .bhp-card p:last-child{margin-bottom:0} .bhp-aav .bhp-facts{display:grid;grid-template-columns:repeat(4,1fr);gap:.7rem;margin:1rem 0 .2rem} .bhp-aav .bhp-fact{background:var(--mist);border:1px solid var(--line);border-radius:11px;padding:.85rem .9rem} .bhp-aav .bhp-fact .k{font-size:.7rem;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:var(--muted);display:block;margin-bottom:.25rem} .bhp-aav .bhp-fact .v{font-size:1.0rem;font-weight:700;color:var(--ink);word-break:break-word} .bhp-aav .bhp-note{margin-top:1rem;padding:.85rem 1rem;border-left:3px solid var(--vm);background:var(--vw);border-radius:0 10px 10px 0;font-size:.96rem;color:var(--ink-soft);font-style:italic} .bhp-aav .bhp-grid2{display:grid;grid-template-columns:1fr 1fr;gap:1.1rem;margin-bottom:1.1rem} .bhp-aav .bhp-grid2 .bhp-card{margin-bottom:0;height:100%} .bhp-aav ul.bhp-list{list-style:none;margin:.3rem 0 0;padding:0} .bhp-aav ul.bhp-list li{position:relative;padding:.55rem 0 .55rem 1.9rem;color:var(--ink-soft);font-size:1rem;border-bottom:1px solid var(--mist)} .bhp-aav ul.bhp-list li:last-child{border-bottom:none} .bhp-aav ul.bhp-check li::before{content:\"\\2713\";position:absolute;left:.15rem;top:.55rem;color:var(--teal);font-weight:800} .bhp-aav ul.bhp-step li::before{content:\"\\25B8\";position:absolute;left:.3rem;top:.55rem;color:var(--amber);font-weight:800} .bhp-aav .bhp-head.amber .bhp-ico{background:var(--amber-wash);color:var(--amber);border-color:#f0dcbf} .bhp-aav .bhp-valid{border:1px solid #cfe9e7;background:linear-gradient(180deg,var(--teal-wash),#fff);border-left:5px solid var(--teal)} .bhp-aav .bhp-valid .bhp-ico{background:var(--teal-wash);color:#0b6e6b;border-color:#cfe9e7} @media(max-width:880px){.bhp-aav .bhp-facts{grid-template-columns:repeat(2,1fr)}.bhp-aav .bhp-grid2{grid-template-columns:1fr}.bhp-aav .bhp-htitle{font-size:1.6rem}} @media(max-width:480px){.bhp-aav .bhp-facts{grid-template-columns:1fr}.bhp-aav .bhp-card{padding:1.3rem 1.25rem}} \u003c\/style\u003e\u003cdiv class=\"bhp-aav\"\u003e \u003cheader class=\"bhp-hero\"\u003e\u003cspan class=\"bhp-kicker\"\u003eRecombinase \/ driver · Research Use Only\u003c\/span\u003e\u003ch2 class=\"bhp-htitle\"\u003eCRISPR sgRNA Control Vector\u003c\/h2\u003e\n\u003cp class=\"bhp-hsub\"\u003eConstitutive expression of Cre driven by the U6 + Nestin (dual) promoter.\u003c\/p\u003e\n\u003cdiv class=\"bhp-chips\"\u003e\n\u003cspan class=\"bhp-chip\"\u003eU6 + Nestin (dual) promoter\u003c\/span\u003e\u003cspan class=\"bhp-chip\"\u003eConstitutive\u003c\/span\u003e\u003cspan class=\"bhp-chip\"\u003eTranscriptional regulator \/ recombinase\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/header\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M9 3v4M15 3v4M9 7c0 4-3 5-3 9a6 6 0 0 0 12 0c0-4-3-5-3-9\"\u003e\u003c\/path\u003e\u003cpath d=\"M8 14h8\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eResearch background\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eThis AAV provides recombinase-based genetic access, enabling conditional control of downstream payloads in genetically defined cells. Recombinase tools are widely used to restrict expression, create intersectional logic, or enable lineage\/cell-type targeting.\u003c\/p\u003e\u003c\/section\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"3\"\u003e\u003c\/circle\u003e\u003cpath d=\"M12 2v3M12 19v3M2 12h3M19 12h3M5 5l2 2M17 17l2 2M19 5l-2 2M7 17l-2 2\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eMechanism and expected readouts\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eRecombinase expression catalyzes site-specific DNA recombination at matching target sites, permanently switching genetic states in infected cells. This can gate expression of FLEX\/DIO payloads or enable intersectional strategies when combined with other recombinases.\u003c\/p\u003e\u003c\/section\u003e \u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M4 7h16M4 12h10M4 17h7\"\u003e\u003c\/path\u003e\u003ccircle cx=\"18\" cy=\"15\" r=\"3\"\u003e\u003c\/circle\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eExpression design and interpretation\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eExpression is driven by the U6 + Nestin (dual) promoter, which determines where and how strongly the payload is expressed in your system (dual-promoter design — U6 (Pol III) transcribes the sgRNA; Nestin (Pol II) drives the protein cassette in neural stem and progenitor cells). The construct's regulatory logic controls where\/when the payload is active; expression is constitutive (no recombinase or inducer required). The encoded payload is intended to support the stated experimental function (e.g., modulation, sensing, labeling, or control). Two independent transcription units operate here: U6 is a compact RNA polymerase III promoter optimized for short, non-polyadenylated transcripts such as guide RNAs, while Nestin is an RNA polymerase II promoter giving strong protein-level expression of the reporter. Because the guide is a scramble\/non-targeting control, the vector reproduces the non-specific effects of sgRNA expression and AAV transduction without acting on a target gene.\u003c\/p\u003e\n\u003cdiv class=\"bhp-facts\"\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003ePromoter\u003c\/span\u003e\u003cspan class=\"v\"\u003eU6 + Nestin (dual)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eExpression control\u003c\/span\u003e\u003cspan class=\"v\"\u003eConstitutive\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eReporter \/ tag\u003c\/span\u003e\u003cspan class=\"v\"\u003eNone\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bhp-fact\"\u003e\n\u003cspan class=\"k\"\u003eLocalization\u003c\/span\u003e\u003cspan class=\"v\"\u003eConfirm by imaging\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"bhp-note\"\u003eSubcellular targeting elements (when present) can bias localization and should be confirmed by imaging in your preparation.\u003c\/p\u003e\u003c\/section\u003e \u003cdiv class=\"bhp-grid2\"\u003e\n\u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M20 6 9 17l-5-5\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eCommon research applications\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cul class=\"bhp-list bhp-check\"\u003e\n\u003cli\u003eConditional targeting for cell-type or projection-specific experiments\u003c\/li\u003e\n\u003cli\u003eIntersectional labeling or manipulation strategies\u003c\/li\u003e\n\u003cli\u003ePermanent genetic switching for lineage or fate-mapping workflows\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/section\u003e\u003csection class=\"bhp-card\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M12 9v4M12 17h.01\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.3 3.9 1.8 18a2 2 0 0 0 1.7 3h17a2 2 0 0 0 1.7-3L13.7 3.9a2 2 0 0 0-3.4 0Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eExperimental considerations\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cul class=\"bhp-list bhp-step\"\u003e\n\u003cli\u003eVerify recombination efficiency with a compatible reporter in your system\u003c\/li\u003e\n\u003cli\u003eAccount for irreversible switching when designing longitudinal studies\u003c\/li\u003e\n\u003cli\u003eUse appropriate negative controls (no recombinase or mismatched recombinase lines)\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/section\u003e\n\u003c\/div\u003e \u003csection class=\"bhp-card bhp-valid\"\u003e\u003cdiv class=\"bhp-head\"\u003e\n\u003cspan class=\"bhp-ico\" aria-hidden=\"true\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath d=\"M12 3l7 3v5c0 4.5-3 8-7 10-4-2-7-5.5-7-10V6l7-3Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003ch2 class=\"bhp-h\"\u003eControls and validation\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003eTypical validation includes confirming expression pattern and level, verifying functional activity with an assay matched to the payload (e.g., imaging, electrophysiology, pharmacology, or behavior), and using appropriate negative controls.\u003c\/p\u003e\u003c\/section\u003e \u003c\/div\u003e","brand":"Biohippo Inc","offers":[{"title":"AAV2\/1 \/ 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