{"product_id":"rab22a-antibody-ras-related-protein-rab-22a-bha17135506","title":"RAB22A Antibody \/ Ras related protein Rab-22A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRAB22A Antibody \/ Ras related protein Rab-22A is a anti-RAB22A Rabbit antibody Recombinant Rabbit Monoclonal clone 31R51 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RAB22A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31R51, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRAB22A antibody detects Ras related protein Rab-22A, a member of the Rab family of small GTPases encoded by the RAB22A gene. Rab proteins are key regulators of vesicle trafficking, controlling vesicle formation, motility, tethering, and fusion. RAB22A localizes to early endosomes and recycling endosomes, where it regulates cargo sorting and endosomal membrane dynamics. By cycling between an active GTP bound state and an inactive GDP bound state, RAB22A coordinates membrane trafficking and receptor recycling.\u003cbr\u003e\u003cbr\u003eRAB22A antibody is widely applied in studies of endocytosis, membrane trafficking, and receptor regulation. RAB22A interacts with Rabex-5 and Rabaptin-5 to control early endosome maturation and crosstalk with Rab5 mediated pathways. It also contributes to recycling of transferrin receptors and growth factor receptors to the plasma membrane. By detecting RAB22A, researchers can examine how membrane trafficking proteins influence nutrient uptake, receptor signaling, and cellular homeostasis.\u003cbr\u003e\u003cbr\u003e Western blot assays identify RAB22A protein bands of expected size in cell and tissue lysates. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence reveals punctate distribution consistent with endosomal localization. These techniques make RAB22A antibody versatile for cell biology research.\u003cbr\u003e\u003cbr\u003eDysregulation of RAB22A has been linked to cancer and neurodegeneration. Elevated RAB22A expression enhances receptor recycling and signaling, promoting tumor cell survival, invasion, and therapy resistance. In neurons, altered RAB22A activity contributes to trafficking defects and synaptic dysfunction. By applying RAB22A antibody, scientists can explore how small GTPases regulate intracellular trafficking and disease mechanisms.\u003cbr\u003e\u003cbr\u003eBeyond cancer and neuroscience, RAB22A also participates in immune signaling and pathogen entry. Certain viruses exploit RAB22A regulated endocytosis for infection, highlighting its role in host-pathogen interactions. Its broad biological functions emphasize the importance of RAB22A antibody in both basic and translational research.\u003cbr\u003e\u003cbr\u003eRAB22A antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RAB22A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RAB22A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RAB22A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RAB22A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RAB22A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047293903213,"sku":"FY12603","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b1866495-2c18-4044-a580-252c984c4512.jpg?v=1772019320","url":"https:\/\/www.ebiohippo.com\/products\/rab22a-antibody-ras-related-protein-rab-22a-bha17135506","provider":"BioHippo","version":"1.0","type":"link"}