{"product_id":"rabbit-igg-fc-fragment-bhp10506042","title":"Rabbit IgG Fc fragment","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative rabbit immunoglobulin G (IgG) is purified from Rabbit serum IgG and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFragment format (Fc):\u003c\/strong\u003e Contains the constant Fc region without antigen-binding domains, enabling Fc-focused studies.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Other Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eCommon names \/ aliases:\u003c\/strong\u003e fragment crystallizable region\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eImmunoglobulin G (IgG) is a Y-shaped antibody composed of two heavy and two light chains, with antigen-binding Fab regions and an Fc region that can engage Fc receptors and complement. IgG is central to humoral immunity and is widely used as a reference reagent for immunoassays, Fc biology studies, and antibody engineering research.\u003c\/p\u003e\u003cp\u003eThe fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eFc glycosylation and Fc receptor signaling as drivers of antibody effector function and immune modulation.\u003c\/li\u003e \u003cli\u003eAntibody fragmentation and engineering strategies used to dissect antigen binding vs Fc-mediated interactions.\u003c\/li\u003e \u003cli\u003eAssay standardization efforts that use well-defined IgG materials to improve quantitative comparability across platforms.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eCalibration\/controls for immunoassays and secondary antibody workflows where IgG is a common analyte or standard.\u003c\/li\u003e \u003cli\u003eFc receptor and complement engagement studies (conceptual) that separate binding from downstream effector mechanisms.\u003c\/li\u003e \u003cli\u003eBenchmark reagent in antibody purification, formulation, and stability method development.\u003c\/li\u003e \u003cli\u003eFc receptor\/complement interaction concepts and assay benchmarking where antigen binding is intentionally absent.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eGlycosylation patterns on the Fc region can vary by species and source and can influence Fc receptor\/complement interactions.\u003c\/li\u003e \u003cli\u003ePolyclonal IgG preparations represent a mixture of specificities; interpret binding results accordingly.\u003c\/li\u003e \u003cli\u003eFragment formats (Fc\/Fab) change which interactions are possible; align fragment choice to the biology you want to probe.\u003c\/li\u003e \u003cli\u003eFc fragments lack Fab-mediated antigen binding; observed effects reflect Fc-dependent interactions and solution properties.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=immunoglobulin G IgG structure Fc receptor - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=immunoglobulin G IgG structure Fc receptor - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=immunoglobulin G IgG structure Fc receptor%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"10 mg","offer_id":53052973285741,"sku":"CSB-NP005201Rb-10MG","price":2000.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052973318509,"sku":"CSB-NP005201Rb-1MG","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP005201Rb-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/rabbit-igg-fc-fragment-bhp10506042","provider":"BioHippo","version":"1.0","type":"link"}