{"product_id":"rac3-antibody-ras-related-c3-botulinum-toxin-substrate-3-bha17135496","title":"RAC3 Antibody \/ Ras related C3 botulinum toxin substrate 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRAC3 Antibody \/ Ras related C3 botulinum toxin substrate 3 is a anti-RAC3 Rabbit antibody Recombinant Rabbit Monoclonal clone 32R19 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RAC3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32R19, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRAC3 antibody detects Ras related C3 botulinum toxin substrate 3, a small GTP binding protein encoded by the RAC3 gene. RAC3 belongs to the Rho family of small GTPases, which regulate actin cytoskeleton dynamics, cell adhesion, migration, and signaling. Like other Rho GTPases, RAC3 cycles between an inactive GDP bound state and an active GTP bound state, controlled by guanine nucleotide exchange factors and GTPase activating proteins. Through its activity, RAC3 contributes to cell proliferation, survival, and polarity.\u003cbr\u003e\u003cbr\u003eRAC3 antibody is widely used in cancer research, neuroscience, and cell signaling studies. RAC3 promotes lamellipodia formation and actin remodeling, driving cell migration and invasion. In cancer, elevated RAC3 expression has been linked to tumor progression, metastasis, and therapy resistance. By detecting RAC3, researchers can study how GTPase signaling influences cytoskeletal regulation and oncogenic transformation.\u003cbr\u003e\u003cbr\u003e Western blot assays detect RAC3 protein in diverse tissues and cell lines. Immunohistochemistry reveals expression in epithelial tissues and tumor samples, while immunofluorescence highlights subcellular distribution at lamellipodia and cell junctions. ELISA applications enable quantitative assessment of RAC3 expression across experimental samples.\u003cbr\u003e\u003cbr\u003eRAC3 also plays roles in neuronal development and plasticity. In the brain, RAC3 regulates axon guidance, dendritic spine formation, and synaptic signaling. Dysregulation of RAC3 has been associated with intellectual disability, psychiatric disorders, and neurodegeneration. By applying RAC3 antibody, scientists can evaluate how GTPase signaling contributes to neuronal structure and function.\u003cbr\u003e\u003cbr\u003eBeyond the nervous system and cancer, RAC3 participates in immune responses, angiogenesis, and wound healing. Its broad impact across tissues makes it an important target for basic and translational research. The antibody therefore serves as a versatile reagent for exploring cytoskeletal and signaling pathways across biology.\u003cbr\u003e\u003cbr\u003eRAC3 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RAC3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RAC3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RAC3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RAC3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RAC3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047293182317,"sku":"FY12593","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4d55bb37-5d67-458d-a60a-031d5d8c80c6.jpg?v=1772019312","url":"https:\/\/www.ebiohippo.com\/products\/rac3-antibody-ras-related-c3-botulinum-toxin-substrate-3-bha17135496","provider":"BioHippo","version":"1.0","type":"link"}