{"product_id":"rassf7-antibody-ras-association-domain-containing-protein-7-bha17135224","title":"RASSF7 Antibody \/ Ras association domain-containing protein 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRASSF7 Antibody \/ Ras association domain-containing protein 7 is a anti-RASSF7 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RASSF7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRASSF7 antibody is designed for the study of Ras association domain family member 7, a centrosome-associated protein that regulates microtubule dynamics, spindle formation, and mitotic progression. Unlike many RASSF proteins that interact with Hippo pathway kinases, RASSF7 lacks a SARAH domain and instead functions primarily at the centrosome. Here, it maintains spindle pole integrity and ensures accurate chromosome segregation, processes that are essential for successful cell division and prevention of genomic instability. Researchers can use RASSF7 antibody to explore how centrosomal regulation intersects with Ras effector pathways in both healthy and diseased states.\u003cbr\u003e\u003cbr\u003eDuring mitosis, Ras association domain family member 7 controls the growth and stability of microtubules, supporting the attachment of chromosomes and the function of spindle poles. When RASSF7 expression is lost, cells exhibit spindle defects, prolonged mitotic arrest, and activation of apoptotic pathways. These findings have established RASSF7 as a safeguard for cell cycle fidelity. Beyond mitosis, the protein influences cell morphology by regulating microtubule outgrowth in interphase cells. This control of cytoskeletal organization allows RASSF7 to contribute to processes such as cell migration, adhesion, and tissue morphogenesis.\u003cbr\u003e\u003cbr\u003eDevelopmental biology studies highlight the broad significance of RASSF7. Expression of this protein is observed in the nervous system, hematopoietic tissues, and embryonic structures. Model organisms such as zebrafish have demonstrated that depletion of RASSF7 leads to developmental arrest, neural patterning defects, and widespread apoptosis, underscoring its essential role in early life. For scientists examining embryogenesis or neural development, RASSF7 antibody provides a practical tool to monitor how centrosomal proteins coordinate cell division and differentiation during critical growth phases.\u003cbr\u003e\u003cbr\u003eCancer research has further elevated interest in Ras association domain family member 7. Abnormal expression or silencing of RASSF7 has been documented in melanoma, glioblastoma, and lung carcinoma. Because cancer cells rely on accurate spindle formation to proliferate, disruption of RASSF7 may accelerate chromosomal instability and drive tumor progression. Conversely, some studies suggest that overexpression of RASSF7 may allow tumor cells to adapt to oncogenic stress by stabilizing microtubules under unfavorable conditions. This dual nature makes RASSF7 a compelling protein to study in oncology, and RASSF7 antibody is central to these investigations.\u003cbr\u003e\u003cbr\u003eLaboratories can apply RASSF7 antibody in a range of assays. In immunohistochemistry, it highlights centrosome-associated staining patterns in dividing cells, providing context for tissue proliferation and tumor grading. In western blotting, it quantifies protein expression and reveals changes under mitotic stress or drug treatment. Immunofluorescence microscopy using RASSF7 antibody enables visualization of spindle structures and centrosome organization, helping to link protein localization with functional outcomes. These experimental approaches allow researchers to assess how RASSF7 contributes to both normal physiology and pathological transformation.\u003cbr\u003e\u003cbr\u003eThe RASSF7 antibody available from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RASSF7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RASSF7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RASSF7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RASSF7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RASSF7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286563181,"sku":"FY12321","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_40aa2586-d05e-41e5-88d7-7366c057e7a5.jpg?v=1782237021","url":"https:\/\/www.ebiohippo.com\/products\/rassf7-antibody-ras-association-domain-containing-protein-7-bha17135224","provider":"BioHippo","version":"1.0","type":"link"}