{"product_id":"rat-serpin-a12-elisa-kit-picokine-bhe21001597","title":"Rat Serpin A12 ELISA Kit PicoKine®","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Serpin A12, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin, Serpina12.\u003c\/p\u003e\u003cp\u003eRat \u003cstrong\u003eSerpin A12\u003c\/strong\u003e (\u003cstrong\u003eSerpina12\u003c\/strong\u003e) is widely studied as a molecular readout in experimental models where changes in protein abundance reflect underlying biology. This target is frequently investigated in \u003cstrong\u003eMolecular \u0026amp; Cellular Biology\u003c\/strong\u003e research contexts. Proteases and extracellular matrix (ECM) components are central to tissue architecture and remodeling. In many experimental contexts, changes in ECM-related proteins reflect shifts in cell adhesion, migration, barrier integrity, or matrix turnover.\u003c\/p\u003e\u003ch2\u003eBiological function and remodeling context\u003c\/h2\u003e\u003cp\u003eMatrix remodeling is influenced by the balance between synthesis and degradation, often regulated by inflammatory cues, mechanical stress, and growth-factor signaling. Protease activity can unmask or release bioactive fragments, while altered ECM composition can feed back on cell behavior through mechanotransduction and receptor engagement.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRemodeling readout:\u003c\/strong\u003e Quantification can support studies of fibrosis, wound repair, and invasion models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMicroenvironment state:\u003c\/strong\u003e Levels may reflect stromal activation, barrier disruption, or matrix turnover.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanistic linkage:\u003c\/strong\u003e Pairing with inflammatory and growth-factor markers can clarify drivers of remodeling.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eDisease and translational relevance\u003c\/h2\u003e\u003cp\u003eECM remodeling and protease regulation are frequently discussed in the literature across oncology, cardiovascular, pulmonary, and inflammatory disease models. Interpretation of abundance should consider whether the measured analyte represents pro-forms, active forms, or fragments, and whether binding partners in the matrix influence detectability.\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":52920887640429,"sku":"EK1741","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ek1741.png?v=1769078307","url":"https:\/\/www.ebiohippo.com\/products\/rat-serpin-a12-elisa-kit-picokine-bhe21001597","provider":"BioHippo","version":"1.0","type":"link"}