{"product_id":"rat-soluble-receptor-activator-of-nuclear-factor-kb-ligand-srankl-elisa-kit-bhe13700221","title":"Rat Soluble receptor activator of nuclear factor-kB ligand (sRANKL) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eRat Soluble receptor activator of nuclear factor-kB ligand (sRANKL) ELISA Kit has high sensitivity and excellent specificity for detection of Rat TNFSF11. No significant cross-reactivity or interference between Rat TNFSF11 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThis gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT\/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338582876525,"sku":"KTE100068-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338678493549,"sku":"KTE100068-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338678526317,"sku":"KTE100068-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338678559085,"sku":"KTE100068-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE100068.png?v=1778954615","url":"https:\/\/www.ebiohippo.com\/products\/rat-soluble-receptor-activator-of-nuclear-factor-kb-ligand-srankl-elisa-kit-bhe13700221","provider":"BioHippo","version":"1.0","type":"link"}