{"product_id":"rat-transferrin-bhp10506054","title":"Rat Transferrin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative rat transferrin (TF) is purified from e rat serum. and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Carrier Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;90%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eCommon names \/ aliases:\u003c\/strong\u003e Serotransferrin,Beta-1 metal-binding globulin,Siderophilin\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eTransferrin is a glycoprotein that binds ferric iron (Fe³⁺) with high affinity and transports it through blood and extracellular fluids. Cellular iron uptake commonly occurs via transferrin receptor–mediated endocytosis, linking transferrin biology to proliferation, metabolism, and stress responses.\u003c\/p\u003e\u003cp\u003eTransferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg\/L.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eIron homeostasis research intersecting with oxidative stress and ferroptosis, where iron availability and transport pathways are central.\u003c\/li\u003e \u003cli\u003eTransferrin receptor biology in cancer and immune cells as a window into nutrient uptake and activation states.\u003c\/li\u003e \u003cli\u003eGlycosylation and iron-loading state (apo vs holo) as variables influencing binding, trafficking, and assay readouts.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eReceptor-binding and uptake studies to probe transferrin receptor activity in cells and tissues.\u003c\/li\u003e \u003cli\u003eIron-binding\/transfer concepts in biochemical assays, including comparisons of apo- and holo-transferrin behaviors.\u003c\/li\u003e \u003cli\u003eCalibration\/controls for immunoassays and proteomics where transferrin is a common high-abundance plasma protein.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eIron saturation state strongly affects transferrin’s biochemical behavior; interpret results in light of apo\/holo mixtures.\u003c\/li\u003e \u003cli\u003eAs a glycoprotein, transferrin may present glycoform heterogeneity; native preparations can reflect source-dependent variation.\u003c\/li\u003e \u003cli\u003eSpecies differences and plasma-derived co-factors can influence receptor interactions; align the reagent with your experimental model.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=transferrin TF - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=transferrin TF - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=transferrin TF%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"10 mg","offer_id":53052974137709,"sku":"CSB-NP004701r-10MG","price":1495.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052974170477,"sku":"CSB-NP004701r-1MG","price":186.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP004701r-SDS.jpg?v=1772166488","url":"https:\/\/www.ebiohippo.com\/products\/rat-transferrin-bhp10506054","provider":"BioHippo","version":"1.0","type":"link"}