{"product_id":"rbm42-antibody-rna-binding-motif-protein-42-bha17135740","title":"RBM42 Antibody \/ RNA-binding motif protein 42","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRBM42 Antibody \/ RNA-binding motif protein 42 is a anti-RBM42 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RBM42\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRBM42 antibody detects RNA-binding motif protein 42, a nuclear RNA-binding protein involved in post-transcriptional gene regulation, mRNA stability, and stress response. Encoded by the RBM42 gene on chromosome 12q13.12, this protein belongs to the RNA recognition motif (RRM) family and participates in alternative splicing, RNA transport, and translation control. RBM42 plays an important role in maintaining transcriptome stability during stress and in modulating the fate of specific mRNAs involved in cell growth and survival.\u003cbr\u003e\u003cbr\u003eStructurally, RBM42 contains two conserved RRM domains that enable specific binding to U-rich RNA sequences. It interacts with the spliceosome and ribonucleoprotein complexes to regulate pre-mRNA processing. During cellular stress, RBM42 localizes to stress granules and contributes to the sequestration of mRNAs, preventing unwanted translation and preserving RNA integrity until conditions normalize. It also associates with components of the nonsense-mediated decay pathway, suggesting a role in RNA surveillance and turnover.\u003cbr\u003e\u003cbr\u003eThe RBM42 antibody is widely used in molecular biology, RNA processing, and stress signaling research to study post-transcriptional control mechanisms and RNA-protein complex dynamics. Western blot analysis identifies a 45 kilodalton band corresponding to RBM42, while immunofluorescence reveals strong nuclear staining with perinucleolar enrichment under basal conditions. Upon stress induction, cytoplasmic granule localization becomes prominent, consistent with its role in RNA regulation and cellular adaptation.\u003cbr\u003e\u003cbr\u003eRBM42 is implicated in diverse biological processes, including embryonic development, hematopoiesis, and tumor progression. Its expression is upregulated under hypoxia and oxidative stress, contributing to cellular resistance mechanisms. Dysregulation of RBM42 has been associated with aberrant mRNA metabolism in cancers and neurodegenerative diseases, where mis-splicing and altered RNA transport disrupt homeostasis. The RBM42 antibody enables researchers to track these dynamic changes and characterize its role in RNA fate determination.\u003cbr\u003e\u003cbr\u003eFunctionally, RBM42 acts as a molecular chaperone for specific mRNAs, maintaining their stability and coordinating translation with cellular energy states. It interfaces with the ribosomal machinery and modulates translation initiation through mRNA secondary structure binding. The RBM42 antibody provides a powerful reagent for exploring RNA biology, splicing regulation, and cellular stress adaptation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RBM42 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RBM42 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RBM42 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RBM42 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RBM42+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303012717,"sku":"FY12838","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9f861351-bb2e-49b9-944c-2b3003c0456d.jpg?v=1782237045","url":"https:\/\/www.ebiohippo.com\/products\/rbm42-antibody-rna-binding-motif-protein-42-bha17135740","provider":"BioHippo","version":"1.0","type":"link"}