{"product_id":"rbpms2-antibody-rna-binding-protein-with-multiple-splicing-2-bha17135218","title":"RBPMS2 Antibody \/ RNA-binding protein with multiple splicing 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRBPMS2 Antibody \/ RNA-binding protein with multiple splicing 2 is a anti-RBPMS2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RBPMS2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRBPMS2 antibody detects RNA-binding protein with multiple splicing 2, encoded by the RBPMS2 gene on chromosome 15q25.2. RBPMS2 antibody is widely used in developmental biology, muscle biology, and RNA processing research. RBPMS2 belongs to a family of RNA-binding proteins containing RNA recognition motifs that regulate alternative splicing, stability, and translation of target RNAs. Its activity is particularly important in smooth muscle and cardiac muscle development.\u003cbr\u003e\u003cbr\u003eStructurally, RBPMS2 is a ~22 kDa protein with a single RNA recognition motif and a glycine-rich C-terminal region. It localizes to the nucleus and cytoplasm, reflecting dual roles in RNA splicing and translational control. The protein is expressed in the gastrointestinal tract, heart, and developing muscle tissues.\u003cbr\u003e\u003cbr\u003eFunctionally, RBPMS2 regulates alternative splicing of muscle-specific transcripts, supporting differentiation and contractile function. It also stabilizes RNAs involved in muscle signaling pathways and cytoskeletal dynamics. Researchers use RBPMS2 antibody to study RNA regulation, muscle differentiation, and developmental processes.\u003cbr\u003e\u003cbr\u003eClinically, RBPMS2 expression has been implicated in gastrointestinal diseases, cancer, and heart development. Abnormal expression may contribute to smooth muscle dysfunction and tumorigenesis. In zebrafish, RBPMS2 knockdown disrupts heart development, underscoring its conserved role in cardiac biology. \u003cbr\u003e\u003cbr\u003eExperimentally, RBPMS2 antibody is used in western blotting to detect the ~22 kDa protein, in immunofluorescence microscopy to study nuclear-cytoplasmic distribution, and in immunohistochemistry to evaluate tissue expression. RNA immunoprecipitation with RBPMS2 antibody identifies bound transcripts regulating muscle differentiation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RBPMS2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RBPMS2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RBPMS2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RBPMS2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RBPMS2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047284892013,"sku":"FY12315","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ec1d09a9-94dc-4090-8533-b70918d63575.jpg?v=1782237005","url":"https:\/\/www.ebiohippo.com\/products\/rbpms2-antibody-rna-binding-protein-with-multiple-splicing-2-bha17135218","provider":"BioHippo","version":"1.0","type":"link"}