{"product_id":"reck-antibody-reversion-inducing-cysteine-rich-protein-with-kazal-motifs-bha17136137","title":"RECK Antibody \/ Reversion-inducing cysteine-rich protein with Kazal motifs","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRECK Antibody \/ Reversion-inducing cysteine-rich protein with Kazal motifs is a anti-RECK Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RECK\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRECK antibody detects Reversion-inducing cysteine-rich protein with Kazal motifs, a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and suppresses tumor invasion and angiogenesis. The UniProt recommended name is Reversion-inducing cysteine-rich protein with Kazal motifs (RECK). This protein acts as an extracellular matrix (ECM) regulator that maintains tissue integrity and prevents metastasis by inhibiting proteolytic remodeling.\u003cbr\u003e\u003cbr\u003eFunctionally, RECK antibody identifies a 971-amino-acid glycosylphosphatidylinositol (GPI)-anchored protein expressed on the cell surface. RECK directly inhibits MMP2, MMP9, and MMP14, limiting ECM degradation and tumor cell invasion. It also stabilizes tissue inhibitors of metalloproteinases (TIMPs) and modulates Notch and Wnt signaling pathways involved in development and tumor suppression. RECK expression is tightly controlled by transcriptional regulators and epigenetic mechanisms, including promoter methylation and microRNA repression.\u003cbr\u003e\u003cbr\u003eThe RECK gene is located on chromosome 9p13.3 and is broadly expressed in embryonic and adult tissues, including brain, lung, and vascular endothelium. High expression is associated with normal tissue homeostasis and morphogenesis, whereas silencing occurs in many cancers, correlating with poor prognosis.\u003cbr\u003e\u003cbr\u003ePathologically, RECK downregulation promotes cancer metastasis, vascular invasion, and inflammation by unleashing matrix-degrading enzymes. Conversely, forced expression of RECK inhibits tumor angiogenesis and cell migration. RECK deficiency also impairs embryonic vascular development, reflecting its essential role in morphogenesis. Research using RECK antibody supports studies in oncology, extracellular matrix biology, and developmental signaling.\u003cbr\u003e\u003cbr\u003eRECK antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect MMP regulators. \u003cbr\u003e\u003cbr\u003eStructurally, Reversion-inducing cysteine-rich protein with Kazal motifs contains multiple cysteine-rich and Kazal-type serine protease inhibitor domains that confer high affinity for MMP catalytic sites. Its GPI anchor tethers it to the plasma membrane, positioning RECK for local ECM modulation. This antibody enables exploration of RECK's tumor-suppressive mechanisms and its role in cell-matrix interactions.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RECK - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RECK - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RECK - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RECK - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RECK+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320478061,"sku":"FY13235","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e187138e-321e-4483-9a3f-bca6aeea3e9c.jpg?v=1782237094","url":"https:\/\/www.ebiohippo.com\/products\/reck-antibody-reversion-inducing-cysteine-rich-protein-with-kazal-motifs-bha17136137","provider":"BioHippo","version":"1.0","type":"link"}